Pulmonary aspergilloma (mycetoma) usually is a
 saprophytic fungal infection due to aspergillus species
 which colonized and grows into pre-existing cystic/
 cavitary lesions resulting from pulmonary tuberculosis
 or fibrotic sarcoidosis, other fibro-cavitary diseases
 including interstitial lung diseases. Idiopathic pulmonary
 fibrosis (IPF) a rare, chronic, progr...

M any lung diseases, such as severe asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), bronchiectasis and infiltrative pulmonary diseases are associated with chronic neutrophilic inflammation. These diseases are common, can be severe and, together, represent a major economic burden and worldwide public health challenge. In addition to chronic handicap, these diseases al...

Antibiotic therapy in patients currently treated with corticosteroids is common in chronic respiratory diseases when exacerbation symptoms attributable to infection appear. Among them, obstructive diseases such as asthma and chronic obstructive pulmonary disease (COPD) are major health issues affecting hundreds of million people worldwide that are frequently treated with inhaled corticosteroids...

Pulmonary hypertension (PH) is a severe haemodynamic disorder in which the pulmonary artery pressure is persistently elevated, leading to right-sided heart failure and death. Recently, chronic myeloproliferative diseases associated with pulmonary hypertension were included in the group 5 category, corresponding to PH for which the aetiology is unclear and/or multifactorial. In this review we wi...

Chronic obstructive lung disease (COPD) and diffuse parenchymal lung diseases (DPLD), including idiopathic pulmonary fibrosis (IPF) and sarcoidosis, are associated with a high incidence of pulmonary hypertension (PH), which is linked with exercise limitation and a worse prognosis. Patients with combined pulmonary fibrosis and emphysema (CPFE) are particularly prone to the development of PH. Ech...

Lung disease with chronic hypoxia has been associated with cognitive impairment of the subcortical type. Objectives To review the cognitive effects of chronic hypoxia in patients with lung disease and its pathophysiology in brain metabolism. Methods A literature search of Pubmed data was performed. The words and expressions from the text subitems including "pathophysiology of brain hypoxia"...

  Background : There is little evidence about the role of Zafirlukast (a highly selective LTD4 antagonist) in Chronic Obstructive Pulmonary Disease (COPD). The Zafirlukast can reduce the need for short-acting rescue β2 agonists, produce fewer exacerbations of asthma and increased quality of life as possible benefits treatment for asthma. The aim of our study was to evaluate the effects of Zafir...

Pulmonary Hypertension (PH) associated to chronic respiratory diseases is currently classified in the 3rd group, as a mild to moderate form of pre-capillary PH that progressively complicates the prognosis of associated pulmonary disease. In clinical practice, however, some unresolved issues in the respiratory PH should be considered: 1) the PH heterogeneity in some respiratory diseases, such as...