Patients diagnosed with inflammatory bowel disease are known to be at an increased risk of colorectal and liver cancers and of leukemia. In fact, several forms of primary and secondary hematological malignancies were rarely observed during the clinical course of inflammatory bowel diseases. The causal relationship, if any, remains undetermined. Patients needing a prolonged treatment with immu n...

Chronic myeloid leukemia is a disease marked by expanded clonal hematopoiesis; it is incurable by chemotherapy or radiation but is cured in a majority of patients receiving bone marrow transplantation from nonidentical sibling donors, an outcome generally attributed to a T cell-mediated graft-versus-leukemia effect. In this report, we examine the effect of the P210BCR-ABL fusion protein of the ...

Further investigations on phytochemical constituents of dichloromethane extract fromroots of Salvia lachnocalyx (S. lachnocalyx) led to the isolation and identification of eightknown diterpenoids from this plant for the first time. The chemical structures of the purifiedcompounds were elucidated using spectroscopic analyses including EI-MS, 1H and 13C NMR andby compariso...

Haematologica/journal of hematology vol. 88(02):February 2003 229 ics of STI571 in a phase 1 trial in chronic myelogenous leukemia (CML) patients. Proc Am Assoc Cancer Res 2000;41:3468[abstract]. 4. Druker BJ, Lydon NB. Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J Clin Invest 2000;105:3-7. 5. Marin D, Marktel S, Bua M, Olavarria E,...