OBJECTIVE Sulfur mustard (bis-2-(chloroethyl) sulfide) is a chemical warfare agent (military code: HD) causing extensive skin injury. The mechanisms underlying HD-induced skin damage are not fully elucidated. This review will critically evaluate the evidence showing that oxidative stress is an important factor in HD skin toxicity. Oxidative stress results when the production of reactive oxygen ...

Conceptually, irritant contact dermatitis (irritation) and allergic contact dermatitis (ACD) in man should provide the ideal platforms to launch in vitro toxicology into the pantheon of in vitro testing assays. In theory, irritant dermatitis has been considered by most a simple area of cutaneous biology, whereas ACD is a complex area of biology. However, both result in responses that are reason...

Drugs that have antimicrobial, anti-inflammatory and wound-healing effects deserve special attention, sodium-containing drugs are one of them, which is why they used in veterinary medicine.
 The article presents the results experimental studies to study sub-acute toxicity drugs: known – glycetinate 2%, its analogues ovocid 3%, potassium-sodium 1.5% (Na / K, 1.5%).
 was carried out by ...

Silver has been used as an antimicrobial agent for a long time in different forms, but silver nanoparticles (nanosilver) have recently been recognized as potent antimicrobial agents. Although nanosilver is finding diverse medical applications such as silver-based dressings and silver-coated medical devices, its dermal and systemic toxicity via dermal use has not yet been identified. In this stu...

Hypoxia, caused by disrupted vasculature and peripheral vasculopathies, is a key factor that limits dermal wound healing. Factors that can increase oxygen delivery to the regional tissue, such as supplemental oxygen, warmth, and sympathetic blockade, can accelerate healing. Clinical experience with adjunctive hyperbaric oxygen therapy (HBOT) in the treatment of chronic wounds have shown that wo...

The outcome of avian field studies was examined to model the likelihood of mortality. The data were divided into clusters reflecting the type of pesticide application and bird guilds present on site. Logistic regression was used to model the probability of a bird kill. Four independent variables were tested for their explanatory power: a variable reflecting acute oral toxicity and application r...

p-Methylaminophenol Sulfate is a substituted phenol used as a dye and a photographic developer. In skin absorption studies of radioactive p-aminophenol, as much as 11% of the radioactivity was found in the excreta, viscera, and skin of rats. In subchronic and chronic dermal toxicity studies of hair dyes containing p-Methylaminophenol Sulfate, among other active ingredients, no toxicologically s...

Di(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer in consumer products. People are continuously exposed to DEHP through ingestion, inhalation and dermal absorption. From epidemiological studies, has been shown associate with various adverse health effects, such reproductive abnormalities metabolic diseases. Health concerns have raised regarding exposures; therefore, relevant ris...