Protocol renal allograft biopsies allow the early detection of histological damage in the renal allograft even before renal function deterioration or proteinuria appears. Two different lesions have attracted the main interest in protocol biopsy studies: subclinical rejection, namely, the presence of tubulo-interstitial inflammation and chronic allograft nephropathy, nowadays termed interstitial...

for 12th congress of the European Society of Organ Transplantation. October 2005, Geneva. Pas02 Pascual M, Theruvath T, Kawai T, et al. Strategies to improve long-term outcomes after renal transplantation. N Engl J Med 2002; 346: 580-90.Pau99 Paul LC. Perspectives in renal medicine. Chronic allograft nephropathy: an update. Kidney Int 1999;

BACKGROUND Chemokines are involved in the recruitment of leukocytes to vascularized allografts. CCR1 is a receptor for various proinflammatory chemokines and CCR1 blockade reduces renal allograft injury in rabbits. The purpose of the study was to characterize CCR1-positive cells in human renal allografts. METHODS Formalin-fixed, paraffin-embedded allograft nephrectomies (n = 9) and non-involv...

Smoking has adverse effects on health, causing ischemic heart disease, stroke, chronic obstructive lung disease and cancers of the respiratory, gastrointestinal, pancreas, kidney and urinary tract. Smoking causes an acute increase in mean arterial pressure and heart rate. Chronic smoking reduces the renal plasma flow. There is clinical evidence that smoking has adverse effects on renal outcome ...

INTRODUCTION Achievements in short-term graft survival since the introduction of cyclosporine has not been matched by improvement in long-term graft function, and chronic allograft nephropathy remains the second commonest cause of graft attrition over time. We aimed to evaluate the long-term results of conventional immunosuppression by steroid and azathioprine in comparison with cyclosporine-ba...

Cyclosporine elimination in a regimen including sirolimus has been shown to be a safe and effective approach to improve graft function. Nevertheless, it is still unknown whether the functional benefit of CyA withdrawal coincides with a subsequent reduction in histologic lesions of chronic damage or development of chronic allograft nephropathy. This consideration would forecast a reduction in th...

BACKGROUND End-stage renal disease (ESRD) is an important cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). OBJECTIVES To analyze the outcome and prognostic factors of renal transplantation in patients with ESRD due to SLE from January 1986 to December 2013 in a single center. RESULTS Fifty renal transplantations were performed in 40 SLE patients (32 fema...

Background: We aimed to investigate the role of HIF-2α on chronic allograft nephropathy, which is a consequence inflammation and fibrosis. Method: The study was conducted between November 2019 January 2021, patients who had kidney biopsy in our university last two years were included study. 15 with diagnosis nephropathy proven by biopsy, an eGFR below 60 ml/dk for other reasons as non-CAN group...