نتایج جستجو برای: chromatid breaks
تعداد نتایج: 33390 فیلتر نتایج به سال:
This article continues a series of works by the authors devoted to most karyopathological effects vaccines used in agriculture. The test cytogenetic analysis impact caused LTF130 vaccine from an attenuated culture fungus Trichophyton verrucosum TF-130 L VGNKI peripheral blood lymphocytes healthy 30-day-old Holstein Colonial calves. experiment was conducted on material and technical basis two de...
We report the characterization of rdh54+, the second fission yeast Schizosaccharomyces pombe Rad54 homolog. rdh54+ shares sequence and functional homology to budding yeast RDH54/TID1. Rdh54p is present during meiosis with appropriate timing for a meiotic recombination factor. It interacts with Rhp51 and the meiotic Rhp51 homolog Dmc1 in yeast two-hybrid assays. Deletion of rdh54+ has no effect ...
4415 Susceptibility to Fluorescent Light-induced Chromatid Breaks Associated with DNA Repair Deficiency and Malignant Transformation in Culture. Ram Parshad, Katherine K. Sanford, Gary M. Jones, Robert E. Tarone, Harold A. Hoffman, and Alice H. Grier. ':4420 Carcinoembryonic Antigen for Monitoring Patients with Small-Cell Carcinoma of the Lung during Treat ment. T. Phillip Waalkes, Martin D. Ab...
A family is described in which incontinentia pigmenti (IP) is variably expressed in both sexes, compatible with either autosomal dominant or X linked dominant inheritance. This is the first reported instance of an affected male with a positive family history. Immunological studies of the proband showed no significant alteration of immune function. Cytogenetic investigations of the proband and h...
53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
Defective DNA repair by homologous recombination (HR) is thought to be a major contributor to tumorigenesis in individuals carrying Brca1 mutations. Here, we show that DNA breaks in Brca1-deficient cells are aberrantly joined into complex chromosome rearrangements by a process dependent on the nonhomologous end-joining (NHEJ) factors 53BP1 and DNA ligase 4. Loss of 53BP1 alleviates hypersensiti...
The frequency of sister chromatid exchanges (SCE), structural chromosomal aberrations and the number of chromosomes in the peripheral blood lymphocytes from stainless steel welders were studied. The surveys were carried out three times during a period of three years. There were no significant differences in the mean value and variance of SCE frequency among these three surveys both in the welde...
Chromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the terminal 0.1% of the chromosome. Telomeres and subtelomeres are significantly enriched for SCEs, exhibiting rates of SCE per basepair that are at least 1,600 and 160 times greater, res...
Cyclophosphamide, an extensively used cancer chemotherapeutic agent, requires metabolic activation through a mixed-function oxygenase system. The capacity of this agent to produce oncogenic transformation and chromosomal damage, including increases in sister chromatid exchanges, was investigated in cell culture with or without an exogenous liver metabolic activation system. No oncogenic transfo...
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