background: plasmodium vivax is the predominant species causes of malaria with about 90% total annual reported malaria in iran. this study conducted to determine the susceptibility of plasmodium vivax isolates to chloroquine in sistan and balochistan province, southeastern iran. methods: a total 270 subjects with symptomatic malaria and confirmed p. vivax infection completed the designed 28-day...

Understanding the mode of action antimalarials is central to optimizing their use and discovery new therapeutics. Currently used belong a limited series chemical structures mechanisms are coutinuously debated. Whereas involvement reactive species that in turn kill parasites sensitive oxidative stress, accepted for artemisinins, little known about generation such case quinolines or hydroxynaphto...

Plasmodium falciparum causes the most severe form of malaria and is the most common malaria species in sub-Saharan Africa. Chloroquine used to be the most common drug for the treatment of malaria. Due to development of resistance, chloroquine is no longer efficacious in most of the world. The first line option for treatment of P. falciparum is now artemisinin based combination therapy, such as ...

BACKGROUND The predominance of chloroquine-susceptible falciparum malaria in Malawi more than a decade after chloroquine's withdrawal permits contemplation of re-introducing chloroquine for targeted uses. We aimed to compare the ability of different partner drugs to preserve chloroquine efficacy and prevent the re-emergence of resistance. METHODOLOGY/PRINCIPAL FINDINGS Children with uncomplic...

Background to the study: The in vivo antimalarial activities and effects of combining methanol extracts four ferns namely, Nephrolepis biserrata (NB), N. undulata (NU), Platycerium stemaria (PS), P. angolense (PA) randomly with chloroquine, was determined. Methods: were collected, separately air-dried, powdered obtained by cold maceration evaporation vacuo. They subsequently investigated (0-800...

background: nowadays, scourge of malaria as a fatalistic disease has increased due to emergence of drug resistance and tolerance among different strains of plasmodium falciparum . emergence of chloroquine (cq) resistance has worsened the calamity as cq is still considered the most efficient, safe and cost effective drug among other antimalarials. this urged the scientists to search for other al...

background: point mutations in the genes, pfcrt and pfdhfr , have been identified elsewhere as strongly associated with re­sistance to chloroquine (cq) and pyrimethamine, respectively.  methods: using a restriction digestion method, we report the frequency of two important mutations, t76 and asn108, re­spon­sible for conferring resistance to chloroquine and pyrimethamine, respectively, in patie...

A gain-of-function KCNJ2 D172N mutation in KCNJ2-encoded Kir2.1 channels underlies one form of short QT syndrome (SQT3), which is associated with increased susceptibility to arrhythmias and sudden death. Anti-malarial drug chloroquine was reported as an effective inhibitor of Kir2.1 channels. Using biophysically-detailed human ventricle computer models, this study assessed the effects of chloro...

Chloroquine Retinopathy Ideal body weight Dr. F.R. Ochsendorf, Department of Dermatology, University Hospital, Theodor-Stern-Kai 7, D-60590 Frankfurt/M. (Germany) In this journal, Lipsker et al. [1] emphasized the efficacy of the combination of chloroquine and quinacrine for the treatment of resistant cutaneous lupus erythematosus. 20% of their patients (3/15), however, developed abnormalities ...

The resurgence of malaria in recent decades has been accompanied by the worldwide spread of resistance to chloroquine, a drug once uncontested as the first-line antimalarial agent because of its efficacy and low toxicity. Chloroquine-resistant strains of Plasmodium falciparum counter the drug by expelling it rapidly via an unknown mechanism. In the absence of explicit biochemical knowledge of t...