The development of new anticancer agents with lower toxicity, higher therapeutic index, and weaker tendency to induce resistant phenotypes in tumor cells is a continuous challenge for the scientific community. Toward that end, we showed previously that a new class of soft alkylating agents designed as phenyl-3-(2-chloroethyl)ureas (CEUs) inhibits tumor cell growth in vitro and that their effici...

Inexpensive strategies for efficient decontamination of hazardous chemicals are required. In this study, the effect visible light (λ > 400 nm) on decomposition 2-chloroethyl ethyl sulfide (2-CEES, a sulfur mustard (HD) simulant) Au/TiO2 photocatalyst under anaerobic and aerobic conditions has been investigated in situ by diffuse reflectance infrared Fourier –transformed spectroscopy (DRIFTS)...

The capacities to inhibit coumarin 7-hydroxylase activity of human cytochrome P450 2A6 (CYP2A6) by organosulfur compounds were evaluated. Five dialkyl sulfides and five dialkyl disulfides, with alkyl chains from methyl to amyl, were examined. In addition to these chemicals, diallyl sulfide, diallyl disulfide, allyl methyl sulfide, allyl n-propyl sulfide, allyl phenyl sulfide, diphenyl sulfide, ...

The title compounds, (N-methyl-N-phenyl-amino)(N-methyl-N-phenyl-car-bam-oyl)sulfide, C15H16N2OS, (I), and (N-methyl-N-phenyl-amino)-(N-methyl-N-phenyl-carbamo-yl)disulfane, C15H16N2OS2, (II), are stable derivatives of (chloro-carbon-yl)sulfenyl chloride and (chloro-carbon-yl)disulfanyl chloride, respectively. The torsion angle about the S-S bond in (II) is -92.62 (6)°, which is close to the th...

T. VAN OIJEN*, M. A. VAN LEEUWE, E. GRANUM, F. J. WEISSING, R. G. J. BELLERBY, W. W. C. GIESKES AND H. J. W. DE BAAR 1 DEPARTMENT OF MARINE BIOLOGY, CEES, UNIVERSITY OF GRONINGEN, PO BOX 14, 9750 AA HAREN, THE NETHERLANDS, DEPARTMENT OF ANIMAL AND PLANT SCIENCES, UNIVERSITY OF SHEFFIELD, SHEFFIELD S10 2TN, UK, THEORETICAL BIOLOGY, UNIVERSITY OF GRONINGEN, PO BOX 14, 9750 AA HAREN, THE NETHERLAN...

This study examines whether health inequalities exist between lone and cohabiting mothers across Europe, and how these may differ by welfare regime. Data from the European Social Survey were used to compare self-rated general health, limiting long-standing illness and depressive feelings by means of a multi-level logistic regression. The 27 countries included in the analyses are classified into...

HIGHLIGHTS Since the geopolitical developments of 1989, former centrally planned economies of Eastern Europe followed distinctively different pathways in national pharmaceutical expenditure evolution as compared to their free market Western European counterparts.Long term spending on pharmaceuticals expressed as percentage of total health expenditure was falling in free market economies as of 1...

The Occlusion Dose Monitor was first made by Allistair Fielder and Merrick Moseley in the early ninetees (Fielder et al., 1995) and miniaturized, following a suggestion by Paul van der Maas, the initiator of the RAMSES birth-cohort study on vision sceening (Groenewoud et al., 2010), by Cees Romijn and other electrotechnicians at the Academical Medical Center in Amsterdam in 1996 and 1997 (Simon...

Changes in the market conditions for fruit and vegetables have induced Dutch co-operative auctions to restructure their sales and marketing activities. Nine auctions merged into VTN and established the marketing organisation The Greenery International BV. VTN/The Greenery have encountered many problems in their first years of operation. Part of these problems can be explained by the lack of org...