The aim of this study was to formulate buccal mucoadhesive nanoparticles (NPs) using the natural mucoadhesive polymers. The natural mucoadhesive polymers chitosan (CS) and dextran sulfate sodium salt (DS) were used to prepare mucoadhesive NPs using the ionic gelation method. As the molecular weight of DS decreased, the amount of mucin and the number of buccal cells adsorbed on DS increased. The...

Many strategies have been developed to improve vaccine delivery in the past decade. The aim of the current study was to develop a nanoparticulate system based on ionic gelation between chitosan and tripolyphosphate in order to load Androctonus Crassicauda scorpion venom. The best formulation was selected according to the highest association efficiency, loading capacity, optimum particle size an...

<p>Penelitian ini bertujuan untuk memodifikasi kitosan dan digunakan sebagai sensor ion logam Cu(II). Modifikasi dilakukan dengan penaut silang menggunakan tripolifosfat dibentuk menjadi membran. Membran yang dihasilkan dianalisis spektrofotometer UV-Vis, <em>Fourier Transform InfraRed </em>(FTIR), <em>Scanning Electron Microscope-Energy Dispersive X-Ray</em> (SEM-...

Objective(s): This study considered the combination of chitosan nanoparticles with antioxidant-antibacterial fraction extracted from Lactobacillus casei and investigation of possible increasing of antibacterial activity of the fraction in hybrid nanoparticle and the effect of the fraction on the stability of chitosan nanoparticles. Methods: Extra...

Bundung plant extract contains flavonoid secondary metabolite compounds that have the potential to kill Staphylococcus aureus bacteria and inhibit fungus Candida albicans. Its utilization uses nanoparticle technology because ability penetrate cell walls can be penetrated by size of colloidal particles. Nanoparticles are technologies a 10-1000 nm. The formation nanoparticles using chitosan polym...

This study aims to co-microencapsulate the Ruellia tuberosa L. and Cosmos caudatus K. extracts, with chitosan–sodium tripolyphosphate (Na-TPP) as coating material. α-Amylase inhibition antioxidant assays were conducted determine potential of microcapsules used antidiabetic agents. The manufactured under influences pH, Na-TPP concentration, stirring time. optimum microencapsulation conditions se...

objective(s): nanoparticles (nps) are known for their specific accumulation in the inflamed tissues of the colon and thus allow a selective delivery to the site of inflammation with minimum adverse effects. the main objective of this work is to attain mesalamine loaded chitosan nanoparticles as a carrier for oral delivery. methods: in this study, mesalamine loaded chitosan nanoparticles were pr...

Silicon-substituted calcium phosphate (Si-CaP) was developed in our laboratory as a biomaterial for delivery in bone tissue engineering. It was fabricated as a 3D-construct of scaffolds using chitosan-trisodium polyphosphate (TPP) cross-linked networks. In this study, heparin was covalently bonded to the residual -NH2 groups of chitosan on the scaffold applying carbodiimide chemistry. Bonded he...