BACKGROUND AND THE PURPOSE OF THE STUDY Studies show that chitosan nanoparticles increase mucoadhesivity and penetration of large molecules across mucosal surface. The aim of the present study was to investigate the use of thiolated chitosan in the development of polysaccharide-coated nanoparticles in order to confer specific functionality to the system. METHODS Methyl methacrylate nanopartic...

Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 3(2) full factorial design was applied to optimize the concentration of chitosan and HPMC. T...

abstract seafood is valuable protein sources for human being and acts important role in a healthy diet. due to probability of fish contamination, from catch time to consume time with different microorganisms, there’s different technics to prevent fish spoilage. the present study purposed to investigate the effect of encapsulated thyme (zataria multiflora boiss) extract and chitosan to inhibit l...

Lysozyme hydrolyses ?-(1,4) linkages between d -glucosamine and N -acetyl- units in chitosan, degrades one of the bifunctional crosslinks chitosan–genipin hydrogels. Degraded particles have potential to be renally excreted vivo .

Macroporous chitosan spheres encapsulating superparamagnetic iron oxide nanoparticles were synthesized by a facile and effective one-step fabrication process. Ferro-gels containing ferrous cations, ferric cations and chitosan were dropped into a sodium hydroxide solution through a syringe pump. In addition, a sodium hydroxide solution was employed for both gelation (chitosan) and co-precipitati...

The objective of this study is to develop suitable formulations to improve the dissolution rate of poorly water soluble drugs. We selected lipid-based formulation as a drug carrier and modified the surface using positively charged chitosan derivative (HTCC) to increase its water solubility and bioavailability. Chitosan and HTCC-coated lipid particles had higher zeta-potential values than uncoat...

This study reports that tumor-targeting glycol chitosan nanoparticles with physically loaded and chemically conjugated photosensitizers can be used in photodynamic therapy (PDT). First, the hydrophobic photosensitizer, chlorin e6 (Ce6), was physically loaded onto the hydrophobically-modified glycol chitosan nanoparticles (HGC), which were prepared by self-assembling amphiphilic glycol chitosan-...

Aluminum sulfate (alum), ferrous sulfate, ferric chloride and ferric chloro-sulfate were commonly used as coagulants. However, a possible link of Alzheimer’s disease with conventional aluminium based coagulants has become an issue in wastewater treatment. Hence, special attention has shift towards using biodegradable polymer, chitosan in treatment, which are more environmental friendly. Moreove...

This study investigates the removal of tungsten from simulated water using biopolymer coated particles (i.e. chitosan coated clay) and natural clay. The effects of initial tungsten concentration (from 20 to 500 ppm) and water pH (4, 5.5 and 6.4) on zeta potential and tungsten removal were studied for both chitosan coated clay and natural clay. It was found that the net surface charge of natural...

A successful gene delivery system requires efficiency and stability during storage. Stability studies are imperative for nanomedicines containing biotechnological products such as plasmids and targeting peptides. Chitosan-DNA-FAP-B nanoparticles are novel non-viral vectors for specific gene delivery to the lung epithelial cells. In this study, the storage stability of chitosan-DNA-FAP-B nanopar...