نتایج جستجو برای: chitosan oligomers

تعداد نتایج: 26698  

2011
James C.K. Lai Wenjuan Gao Solomon W. Leung

We have systematically examined the effects of chitosan film or chitosan in combination with nanometal particles (nanogold or nanosilver particles) on the growth of Schwann cells (S16) and DRG neurons (50B 11). Our results strongly suggest chitosan and chitosan in combination with nanogold particles had no effects on the growth kinetics of Schwann cells but had slightly slowed those of DRG neur...

2015
Oana Maria Dragostin Sangram Keshari Samal Florentina Lupascu Andreea Pânzariu Peter Dubruel Dan Lupascu Cristina Tuchilus Cornelia Vasile Lenuta Profire Hitoshi Sashiwa

The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan deri...

2007
Yi Hu Yangzhe Wu Jiye Cai Yufeng Ma Bin Wang Ke Xia Xiaoqing He

In this paper, we investigated the self-assembly and fractal feature of chitosan and Ag (I), Cu (II)-chitosan due to the theoretical and practical importance of chitosan in biomedical engineering, biomaterials and environmental sciences etc. The self-assembly and fractal structures of chitosan and Ag (I), Cu (II)-chitosan were observed using atomic force microscope (AFM), and the fractal dimens...

2018
Xiaoying Kong Wenhua Xu Cuiping Zhang Wei Kong

In the present study, a temperature-sensitive gel composed of chitosan, carboxymethyl chitosan and glycerophosphate was prepared and loaded with chitosan microspheres encapsulating levofloxacin. The bioavailability of levofloxacin and the safety of this novel opthalmic drug delivery formulation were evaluated. Levofloxacin chitosan microspheres were prepared using the ionic gelation method, and...

2017
Estefânia V. R. Campos Jhones L. Oliveira Leonardo F. Fraceto

Chitosan, a polyaminosaccharide obtained by alkaline deacetylation of chitin, possesses useful properties including biodegradability, biocompatibility, low toxicity, and good miscibility with other polymers. It is extensively used in many applications in biology, medicine, agriculture, environmental protection, and the food and pharmaceutical industries. The amino and hydroxyl groups present in...

Journal: :International journal of molecular sciences 2015
Mayumi Egusa Ryo Iwamoto Hironori Izawa Minoru Morimoto Hiroyuki Saimoto Hironori Kaminaka Shinsuke Ifuku

Chitosan produced by the deacetylation of chitin is a cationic polymer with antimicrobial properties. In this study, we demonstrate the improvement of chitosan properties by nanofibrillation. Nanofiber sheets were prepared from nanofibrillated chitosan under neutral conditions. The Young's modulus and tensile strength of the chitosan NF sheets were higher than those of the chitosan sheets prepa...

2013
Changkyu Lee Ji Su Choi Insoo Kim Kyung Taek Oh Eun Seong Lee Eun-Seok Park Kang Choon Lee Yu Seok Youn

Inhalable glycol chitosan-coated poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing palmitic acid-modified exendin-4 (Pal-Ex4) (chitosan Pal-Ex4 PLGA NPs) were prepared and characterized. The surface morphology, particle size, and zeta potential of chitosan Pal-Ex4 PLGA NPs were investigated, and the adsorption and cytotoxicity of chitosan Pal-Ex4 PLGA NPs were evaluated in human lun...

2015
Kazuo Azuma Ryotaro Izumi Tomohiro Osaki Shinsuke Ifuku Minoru Morimoto Hiroyuki Saimoto Saburo Minami Yoshiharu Okamoto

Chitin (β-(1-4)-poly-N-acetyl-D-glucosamine) is widely distributed in nature and is the second most abundant polysaccharide after cellulose. It is often converted to its more deacetylated derivative, chitosan. Previously, many reports have indicated the accelerating effects of chitin, chitosan, and its derivatives on wound healing. More recently, chemically modified or nano-fibrous chitin and c...

2013
Hualin FU Zhirong ZHANG Tao GONG

Deacetylation degree (DD) is one of the most important characteristics of chitosan and has great impact on its physicochemical and biological properties. In this study, three kinds of chitosan with different DD were prepared. By means of living imaging technique and fluorescent quantitative technique, the influences of different DD on the distribution of chitosan in vivo were investigated. The ...

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