Nucleic acid (NA) extraction is a basic step for genetic analysis, from scientific research to diagnostic and forensic applications. It aims at preparing samples its application with biomolecular technologies such as isothermal non-isothermal amplification, hybridization, electrophoresis, Sanger sequencing next-generation sequencing. Multiple steps are involved in NA collection raw samples, inc...

Lab-on-Chip (LoC) devices are on the verge of revolutionizing clinical diagnostics and point-of-care applications. These devices can integrate miniaturized laboratory functions (such as separation and analysis of components of a mixture) on a single chip using extremely small fluid volumes. For example, in the health care industry, an electrophoresis chip is fabricated for monitoring lithium in...

This paper presents a capillary-to-microchip connection, which can be used as an interface for coupling capillary electrophoresis (CE) with a thermal lens microscope (TLM). It is difficult to directly apply TLM to samples in a capillary with a curved surface, and such an interface chip at the end of a CE separation column is needed for reliable TLM measurements. The dependence of the TLM signal...

An isothermal signal amplification technique for specific DNA sequences, known as cycling probe technology (CPT), was performed within a microfluidic chip. The presence of DNA from methicillin-resistant Staphylococcus aureus was determined by signal amplification of a specific DNA sequence. The microfluidic device consisted of four channels intersecting to mix the sample and reagents within 55 ...