نتایج جستجو برای: children thalassemia
تعداد نتایج: 482727 فیلتر نتایج به سال:
BACKGROUND The β-Thalassemia syndromes are the most common hereditary chronic hemolytic anemia due to impaired globin chain synthesis. Vascular endothelial growth factor (VEGF) plays several roles in angiogenesis which is a crucial process in the pathogenesis of several inflammatory, autoimmune and malignant diseases. Endothelial damage and inflammation make a significant contribution to the pa...
OBJECTIVES To describe clinical events of sickle cell disease and the correlation with β-globin haplotypes and α-thalassemia in under 6-year-old children. METHODS A retrospective study was conducted of under 6-year-old children from the neonatal screening program in Rio de Janeiro. Forty-eight male and 48 female children were enrolled in this study, 79 with sickle cell anemia and 17 with hemo...
BACKGROUND Serum haptoglobin (Hp) is a reliable marker for hemolysis regardless the inflammatory state. OBJECTIVE We investigated the possible relation between Hp depletion and hemolysis severity, hepatitis C virus (HCV) infection and iron load in β-thalassemia children. METHODS Twenty two β-thalassemia major (TM),20 β-thalassemia intermedia (TI) children with 20 age and sex matched healthy...
BACKGROUND Beta-thalassemia is the most common hematology disease in human and leptin is one of the hormone that produce by adiposities cells. The purpose of this study was to investigate the relationship between serum leptin level and thyroid hormones in children with major beta-thalassemia. MATERIALS AND METHODS This descriptive-cross sectional study was performed on 90 children aged 6-16 y...
Children with thalassemia can thrive with quality care by their families. The purpose of this study was to examine predictors of family care behavior by family caregivers of children with thalassemia. Eighty-eight family caregivers for children with thalassemia aged 1-16 years were recruited by purposive sampling from in-patient and out-patient clinics in an eastern regional hospital in Thailan...
OBJECTIVE To assess the quality of life among children and adolescents with thalassemia major. METHODS This cross-sectional study used the Pediatric Quality of Life Inventory (PedsQL). Children and adolescents with beta-thalassemia major who attended the Day Care Unit at King Abdulaziz University Hospital, Jeddah, Saudi Arabia from October 2012 to February 2013 were surveyed. The questions hi...
Premarital screening (PMS) can be an important tool to detect of carriers of hemoglobinopathies. The aim of this study was to assess the knowledge and attitude of premarital couples about Thalassemia before PMS in Denizli province. This cross-sectional study was conducted between August-December 2013. The target population was all premarital couples who applied to the City Hemoglobinopathy Cont...
Background: Thalassemia is one of the common inherited blood disorders and Beta Major a homozygous form deficiency beta globin chain synthesis causing severe transfusion-dependent anemia, manifesting between 6 24 months life. Objectives: The objective study to pattern cardiac function in children adolescents with beta-thalassemia major by 2D Echocardiography its correlation serum ferritin level...
BACKGROUND The objective of this study is to evaluate the prevalence of malocclusion and treatment needs in transfusion dependent β-thalassemia major children. METHODS One hundred transfusion dependent β-thalassemia major children visiting the Department of Pediatrics were selected randomly and evaluated for malocclusion with Angle's classification and Dewey's modification. The orthodontic tr...
Introduction: Thalassemia major is one of the most common chronic blood disorders that is characterized by reduced or lack of production of one or more globin chains. Treatment with transfusion programs, chelating therapy has considerably prolonged survival in thalassemic patients. Studies have demonstrated that chelation therapy regularly can prevent from disorders in growth of thalassemic chi...
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