BACKGROUND Animal and human studies suggest that stress experienced early in life has detrimental consequences on brain development, including brain regions involved in cognitive function. Cognitive changes are cardinal features of depression and posttraumatic stress disorder. Early-life trauma is a major risk factor for these disorders. Only few studies have measured the long-term consequences...

Contrary to the common belief that sensory memory remains unchanged across development in childhood, there have been several previous reports suggesting that the persistence of sensory memory, at least for sounds, increases with age in childhood. Because those previous studies all used isolated sounds as stimuli, it is not yet clear how this developmental difference influences the recall of sou...

OBJECTIVE To examine relationships between childhood autobiographical memory disturbance (CAMD) and adverse childhood experiences (ACEs) which are defined as common forms of child maltreatment and related traumatic stressors. METHODS We use the ACE score (an integer count of eight different categories of ACEs) as a measure of cumulative exposure to traumatic stress during childhood. In a cros...

The capacity to retain information for brief periods of time increases dramatically during the childhood years. The increases in temporary storage of speech-based material that take place in the period spanning the pre-school years and adolescence reflect complex changes in many of the different component processes, including perceptual analysis, construction and maintenance of a memory trace, ...

Source memory involves recollecting the contextual details surrounding a memory episode. When source information is bound together, it makes a memory episodic in nature. Unfortunately, very little is known about the factors that contribute to its formation in early development. This study examined the development of source memory in middle childhood. Measures of executive function were examined...

Although controversy exists about the validity of memories of childhood abuse, little is known about memory function in individuals reporting childhood abuse. This study assessed memories for previously presented words, including the capacity for false memory of critical lures not actually present in the word list, in 63 subjects, including abused women with posttraumatic stress disorder (PTSD)...

Childhood socioeconomic status (SES) predicts executive function (EF), but fundamental aspects of this relation remain unknown: the developmental course of the SES disparity, its continued sensitivity to SES changes during that course, and the features of childhood experience responsible for the SES-EF relation. Regarding course, early disparities would be expected to grow during development if...

Childhood is a critical period for the development of the memory B-lymphocyte repertoire necessary in protective humoral immunity. This study addressed the natural history of memory B cells based on the previous identification of germinal center and mantle zone cells as the probable precursor and mature memory cell populations, respectively. Using flow cytometric quantitation of these B-cell su...

OBJECTIVE To examine the association between cognitive ability in childhood and mid-life cognitive decline in the normal population. DESIGN Longitudinal, population based, birth cohort study. PARTICIPANTS 2058 men and women born in 1946. MAIN STUDY MEASURES Ability in childhood measured by AH4 and test of verbal comprehension at age 15 years. Ability in adulthood measured by the national ...

Adult cognition and age-related cognitive decline can be influenced by dysregulation of the hypothalamic pituitary adrenal axis with concomitant changes in cortisol levels. However, very little is known about the role of childhood cognition and educational attainment in this relationship. Using data from the British 1946 birth cohort, the present study investigated: (1) associations between cor...