BACKGROUND Few risk factors for the childhood leukemia are well established. While a small fraction of cases of childhood leukemia might be partially attributable to some diseases or ionizing radiation exposure, the role of industrial and urban pollution also needs to be assessed. OBJECTIVES To ascertain the possible effect of residential proximity to both industrial and urban areas on childh...

OBJECTIVE To conduct a systematic review to evaluate the evidence for the effect of breastfeeding on the risk of developing childhood leukemia. REVIEW METHODS We sought studies providing data regarding the association of breastfeeding and occurrence of childhood leukemia. Studies were identified by using Medline, HHS Blueprint for Action on Breastfeeding, US Department of Health and Human Ser...

OBJECTIVES We conducted a systematic review and meta-analysis of childhood leukemia and parental occupational pesticide exposure. DATA SOURCES Searches of MEDLINE (1950-2009) and other electronic databases yielded 31 included studies. DATA EXTRACTION Two authors independently abstracted data and assessed the quality of each study. DATA SYNTHESIS Random effects models were used to obtain s...

Various specific chromosome rearrangements, including t(8;21), t(15;17), and inv(16), are found in acute myeloid leukemia (AML) and in childhood acute lymphocytic leukemia (ALL), t(12;21) and t(1;19) are common. We sequenced the translocation breakpoints of 56 patients with childhood ALL or AML harboring t(12;21), t(8;21), t(15;17), inv(16), and t(1;19), and demonstrated, with the notable excep...

background: the purpose of this study was to evaluate long-term changes in bone density profile among survivors of childhood acute lymphoblastic leukemia. patients and methods: this was a 5 year prospective study comprised of thirty-one survivors of childhood acute lymphoblastic leukemia with a mean age of 11.8 (4.6) years, who completed therapy at least 1 year previously (according to the all-...

BACKGROUND Traffic exhaust, refineries and industrial facilities are major sources of air toxics identified by the U.S. Environmental Protection Agency (U.S. EPA) for their potential risk to human health. In utero and early life exposures to air toxics such as benzene and 1,3-butadiene, which are known leukemogens in adults, may play an etiologic role in childhood leukemia that comprises the ma...

Possible associations between environmental hazards and the occurrence of childhood leukemia were investigated in Woburn, MA, for the period 1969-79. Residents of Woburn were concerned over what they perceived to be a large number of childhood leukemia cases; at the same time there was extensive publicity about uncontrolled hazardous waste sites in Woburn, which resulted in its being placed on ...

Aim Childhood chronic myeloid leukemia (CML) is rare myeloproliferative disorder, and diagnosed mostly in adult, representing for 10% of all CML, and accounts for up to 2-3% of all childhood leukemia. Tyrosine kinase inhibitor (TKI), mostly Imatinib mesylate, is now used in the frontline standard treatment of CML in chronic phase. The aim of this study is to investigate the growth effect of TKI...