نتایج جستجو برای: chemoresistance

تعداد نتایج: 5112  

2017
Jing-Jing Guo Hong-Shun Xu Gang Wu Zhen-Yu Ma

Thyroid cancer typically has a good prognosis; however, the risks of recurrence and chemoresistance associated with thyroid cancer remain a cause for concern. Papillary thyroid carcinoma (PTC) comprises 80% of all cases of thyroid carcinoma. A previous study reported that cluster of differentiation (CD) 44+/CD24- PTC cells may contribute to PTC recurrence and chemoresistance; however, the under...

2015
Paola Giglio Gian Maria Fimia Penny E Lovat Mauro Piacentini Marco Corazzari

Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apop...

2010
Jörg Fellenberg Pierre Kunz Heiner Sähr Daniela Depeweg

BACKGROUND Chemoresistance is the principal reason for poor survival and disease recurrence in osteosarcoma patients. Inosine 5'-monophosphate dehydrogenase type II (IMPDH2) encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis and has been linked to cell growth, differentiation, and malignant transformation. In a previous study we identified IMPDH2 as an independent p...

Journal: :Oral oncology 2010
Zhi-wei Yu Lai-ping Zhong Tong Ji Ping Zhang Wan-tao Chen Chen-ping Zhang

MicroRNAs (miRNAs) are small non-coding RNAs that function as negative regulators of gene expression. They are strongly implicated in human cancers, including oral squamous cell carcinoma (OSCC). Evidence for the involvement of miRNAs as important regulators of chemosensitivity and chemoresistance in OSCC is not well understood. In this study, miRNA microarray was firstly used to compare the di...

2014
Derek Lamont West Sarah B White Zhouli Zhang Andrew C Larson Reed A Omary

Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal form of cancer. In 2012, the incidence of PDAC was 43,920. Five-year survival for patients with PDAC is around 6%, regardless of staging, making PDAC one of the deadliest forms of cancer. One reason for this dismal prognosis is chemoresistance to the current first-line therapy, gemcitabine. There are multiple factors that contribu...

Journal: :Biomedicine & Pharmacotherapy 2021

Effective cancer therapy requires identification of signaling networks and investigating their potential role in proliferation invasion cells. Among molecular pathways, signal transducer activator transcription 3 (STAT3) has been importance due to its involvement promoting proliferation, cells, mediating chemoresistance. In the present review, our aim is reveal STAT3 pathway bladder (BC), as on...

2014
Weifeng Huang Chunpeng Wan Qicong Luo Zhengjie Huang Qi Luo

Genistein, the predominant isoflavone found in soy products, has exerted its anticarcinogenic effect in many different tumor types in vitro and in vivo. Accumulating evidence in recent years has strongly indicated the existence of cancer stem cells in gastric cancer. Here, we showed that low doses of genistein (15 µM), extracted from Millettia nitida Benth var hirsutissima Z Wei, inhibit tumor ...

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