Combining enzymatic and single-metal-atom catalysis is a promising approach for green chemical synthesis. We herein report one-pot chemoenzymatic cascade reaction to asymmetric synthesize (R)-1-(4-biphenyl) ethanol by using the highly active selective enzyme-metal-single-atom hybrid as catalyst. demonstrate that Pd single atoms anchored lipase (Pd1/CALB-P) can efficiently drive reactions in aqu...

(-)-gephyrotoxin-223 was formally synthesized from chiral synthon 1 which has been chemoenzymatically synthesized  in the presence  of candida antartica lipase.

The self-assembly behavior of chemoenzymatic high molecular weight (ca. 30 000 Da) poly-l-phenylalanine (ePLP) and the nano-morphologies thereof are investigated.

Aqueous chemoenzymatic two-step one-pot enantioselective synthesis of tertiary α-aryl cycloketones via Pd-catalyzed C–C formation and enzymatic CC asymmetric hydrogenation was developed.

Surfactant-enabled asymmetric ATA-catalyzed reductive aminations in aqueous buffered media are described, representative of the enhanced levels conversion made possible by presence a nonionic surfactant water, thereby enabling 1-pot chemoenzymatic catalysis.

The synthesis of substituted d-phenylalanines in high yield and excellent optical purity, starting from inexpensive cinnamic acids, has been achieved with a novel one-pot approach by coupling phenylalanine ammonia lyase (PAL) amination with a chemoenzymatic deracemization (based on stereoselective oxidation and nonselective reduction). A simple high-throughput solid-phase screening method has a...

Purpose: To describe a chemoenzymatic approach joining an enzymatic regioselective hydrolysis of peracetylated N-acetyl-α-D-glucosamine (A) with a mild controlled acyl relocation which resulted 2-acetamido-2 deoxy-1,3,6-tri-O-acetyl-α-D-glucopyranose (1B). Methods: Immobilization of lipase on decaoctyl (DSEOD) and octyl-agarose (OSCL) was carried out as reported by the work of Bastida et al. Th...

A chemoenzymatic approach for synthesizing heparan sulfate oligosaccharides with a reactive diazoacetyl saccharide residue is reported. The resultant oligosaccharides were demonstrated to serve as specific inhibitors for heparan sulfate sulfotransferases, offering a new set of tools to probe the structural selectivity for heparan sulfate-binding proteins.