نتایج جستجو برای: chemically induced
تعداد نتایج: 1002945 فیلتر نتایج به سال:
The antigenicity and immunogenicity of three colorectal carcinomas induced in BALB/c mice by 1,2-dimethylhydra zine orN-methyl-N-nitrosourethan were studied. All tumors were readily transplantable. Two of these tumors metasta sized when transplants reached sufficient size. All tumors were found to be immunogenic in the strain of origin, and all tumors were shown to contain unique tumor-specific...
Hen erythrocytes that were fixed after treatment with lysolecithin in aqueous solution for 30 s at 37 °C showed evidence of bridge formation between adjacent lysed cells. Generally, the homokaryons that were produced using lysolecithin in this way contained large numbers of nuclei. These giant syncytia had damaged nuclear membranes and unstable plasma membranes; complete disintegration of the s...
Possible liver damage induced by chemicals or drugs must be detected early during drug development or industrial exposure, although damage is still difficult to predict, especially when immunotoxicity is involved. Liver toxicity may result from cytolysis, steatosis, cholestasis, phospholipidosis, or vascular lesions, most the outcome of a disadvantageous balance between chemicals or metabolites...
Tendon disorders are frequent both in human and veterinary medicine with high re-injury rates and unsatisfactory therapeutic treatments. Application of naked, chemically-modified mRNA (cmRNA), encoding for therapeutic proteins, is an innovative approach to address tendon healing. In the current study, we demonstrated that injection of naked cmRNA, diluted in a glucose-containing solution, into ...
bout one third of the agents established as carcinogenic to man have affinities for lung. These include defined compounds and the complex mixtures found in tars, oils, soot, car exhausts, and tobacco smoke.’ To understand mechanisms of initiation of these cancers, detailed studies of the biologic actions of specific classes of chemicals have been made. These have implicated DNA as a critical ta...
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