Nucleic acids, especially RNA, naturally contain a diversity of chemically modified nucleosides. To understand the biological role of these modified nucleosides, nucleic acid scientists need tools to specifically label, detect and enrich modified nucleic acids. These tools comprise a diverse set of chemical reagents which have been established in the early years of nucleic acid research. Recent...

Cosmetic industry wastewater is high strength wastewater and it can be difficult to decompose with biological treatment due to its high stability or toxicity. The use of Fenton reagent as a Chemical pretreatment was investigated with a Factorial Experiment where the concentrations of ferrous sulfate, hydrogen peroxide and reaction duration was the main parameters examined for COD and TOC reduct...

The “ex-cell” approach to organic electrosynthesis has enabled important progression be made in numerous systems. Separating out the electrochemical step from subsequent chemical means that substrate scopes can expanded and a broader scope of reagents are more easily prepared. Moieties included otherwise readily undergo single-electron transfer redox events at electrode surface. We detail sever...

Some recent developments in the preparation of polymeric reagents and their use in various chemical reactions are described. Improved polymeric acyl transfer reagents were prepared. They possess good mechanical properties and are therefore easy to handle and pure products are obtained by their use. With one of these polymeric reagents pure peptides may be obtained in high yield in reactions las...

Peptide-Mass Fingerprinting (PMF) encompasses a number of techniques for protein characterization which have as a first step the cleaving of target proteins by chemical or enzymatic reagents. Software systems exist which perform similar analyses. However, this is the first study which examines theoretically the effectiveness of the particular reagents for PMF. In this study, the task of PMF was...

In this paper we present a synthesis method for obtaining hydroxyapatite nanopowders by chemical precipitation. As the starting reagents, analytical grade Ca(OH)2, H3PO4 and NH4OH were used. . In order to study the factors that have an important influence on the chemical precipitation process a experimental platform has been designed for hydroxyapatite synthesis. The experimental platform was d...

Since the seminal work of Butlerov (1863) 1a and Grignard (1900), the addition of preformed organometallic reagents to carbonyl compounds has played a central role in chemical synthesis. While this technology has opened vast volumes of chemical space, the basicity of most organometallic reagents mandates “protection” of acidic substructures, including the ubiquitous hydroxyl group. For the synt...

We have investigated the use of chiral silylating reagents as analytical probes for determining the absolute stereochemistry of natural products by NMR spectroscopy. These reagents are prepared in high chemical yield in one step and can be used to derivatize chiral allylic alcohols which are incompatible with ester-based methodologies. Microscale ( approximately 400 nmol) derivatization conditi...