Proteins of the Chediak-Higashi/Beige (BEACH) family have been implicated in the function of lysosomes, as well as in signal transduction, but their molecular role is still poorly understood. In Dictyostelium, at least six members of the family can be identified. Here cells with mutations in two of these genes, LVSA and LVSB, were analyzed. Interestingly both mutants exhibited defects in the or...

A diminished chemotactic response was observed with the neutrophils of a patient with the Chediak-Higashi syndrome, who was not in the accelerated phase of the disease. An abnormally low release of myeloperoxidase from these cells during phagocytosis was also noted; this resulted in a decreased iodination capacity and probably also caused the defect in the intracellular killing of bacteria by t...

Chemotaxis of mononuclear leukocytes from humans, mink, and cattle was evaluated in vitro using a morphologic Boyden chamber technique and a new labeled mononuclear radioassay with a double micropore filter system. Significantly decreased mononuclear leukocyte chemotactic responses were noted when human, mink, or cattle Chediak-Higashi cells were tested using autologous serum or endotoxin-activ...

Angela-Guiovana Rincón, Elizabeth León, Rodrigo Jiménez, Sandra Parra, Carlos-Andrés Peña y Cesar Pulgarín 1 Laboratory for Environmental Biotechnology, Institute of Environmental Engineering 2 Ecosystem Management Laboratory, Institute of Environmental Engineering 3 Air Pollution Laboratory (LPAS) 4 Logic systems Laboratory (LSL) Swiss Federal Institute of Technology, CHB Ecublens CH 1015 Laus...

1 Departamento de Microbiologı́a I, Inmunologı́a, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain 2 Inmunotek SL, Alcalá de Henares, 28805 Madrid, Spain 3 School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK 4ATR, LLC, Worcester, MA 01606, USA 5Department of Mycobacteriology, National Institute of Infectious Diseases, Higashi-Murayama, Tokyo 189-0002, Japan