shape error due to elastic recovery of formed part in unloading known as springback, is one of the most important problems of tool design in sheet metal forming processes. many researches have been performed for proposing an efficient method to decrease or compensate springback error in sheet forming processes. these methods are usually based on iterative finite element algorithms. in this pape...

mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. it has shown a better efficacy than other drugs in this group. for assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. in this study mutagenic effect of mebudipine was evaluated using ames assay that could assess the mutageni...

objective(s): thyroid hormones play an essential role in fetal growth and maternal hypo-thyroidism which leads to cardiovascular deficiency in their offspring.  considering this, we intended to investigate the impact of gestational hypothyroidism on offspring vascular contractibility and possible underlying mechanisms. materials and methods: hypothyroidism was induced in female rats by administ...

objective(s): angiotensin ⅱ type 1 receptor blockers (arbs) represent one of the widely used antihypertensive agents. in addition to anti-hypertension effect, some arbs also show other molecular effects such as activating peroxisome proliferator-activated receptor-γ and so on. here we studied the effects of telmisartan on the rat isolated mesenteric artery rings pre-contracted by phenylephrine ...

a micro-channel heat exchanger reactor with different micro-baffle shapes has been studied numerically. governing equations were solved base on the finite volume method with fluent software. in upper section, oxidation reaction of methanol was occurred and in lower section, steam reforming of methanol was done. two sections were separated with solid part which played as heat exchanger and trans...

one of the really important challenges facing agricultural producers is the choice of their product distribution channels. the present study is aimed at investigating the citrus marketing channel strategy and its determinants among citrus orchardists of mazandaran using a nested logit model. some two hundred and fifty two orchardists from 15 cities of mazandaran were taken as the study samples....

this paper presents the results of a numerical study on the heat transfer performance and the removal process of fluid particles under the influence of magnetohydrodynamic mixed convection in a horizontal channel with an open cavity. the bottom wall of the cavity is heated at a constant temperature (th) while the top wall of the channel is maintained at a relatively low temperature (tc). air wi...

the advent of e-commerce has prompted many manufacturers to redesign their traditional channel structure by engaging in direct sales. in this paper, we present a dual channel inventory model based on queuing theory in a manufacturer-retailer supply chain, consisting of a traditional retail channel and a direct channel which stocks are kept in both upper and lower echelon. the system receives st...

the goal of this study was to determine the effects of the l-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fkv1.4δn), an n-terminal-deleted mutant of the ferret kv1.4 potassium channel. measurements were made using a two electrode voltage clamp technique with channels expressed stably in xenopus oocytes. the fkv1.4δn currents displayed...

This study makes use of the Tsallis entropy to predict the shear stress distribution. Given a definition of the Tsallis entropy, it is maximized by using the probability density function, which then is used to attain a novel shear stress equation. This is then employed for calculating the shear stress distribution in rectangular channels in different aspect ratios and finally, for viability, th...