The enteric nervous system (ENS), localized in the wall of the gastrointestinal tract, regulates the functions of the intestine using a wide range of neuronally-active substances. One of them is the calcitonin gene-related peptide (CGRP), whose participation in pathological states in the large intestine remains unclear. Therefore, the aim of this study was to investigate the influence of inflam...

BACKGROUND Intrathecal morphine pre-conditioning attenuates cardiac ischemia-reperfusion injury via activation of central opioid receptors. We hypothesized that intrathecal morphine also post-conditions the myocardium in the rat. METHODS Intrathecal morphine at 0.3 μg/kg (LMPC), 3 μg/kg (MMPC) or 30 μg/kg (HMPC) was administered for 5 min before 120-min reperfusion following 30-min ischemia. ...

the aim of this study was to estimate genetic parameters of age at first calving and its relationship with productive traits of holstein dairy cows. a total of 24491 first lactation records (2x 305d) which were collected from 1995 to 2009 were used. the general linear model (glm) procedure was applied to determine effective factors on studied traits. herd-year-season (hys) and age at first calv...

Objective(s) Recent studies on human indicate that the introduction of therapeutic use of tolerogenic dendritic cell (DC) for chronic inflammatory conditions is imminent. For the purpose of defining CGRP potency in tolerogenic DC production, we investigated the phenotype and IL-'2 production of DCs generated from the monocytes of rheumatoid arthritis (RA) patients in the presence of the calcit...

AIMS The haemodynamic effects of adrenomedullin and calcitonin gene-related peptide (CGRP) were studied in resistance and capacitance vessels of healthy volunteers. METHODS Adrenomedullin and CGRP were infused into the brachial artery of eight healthy subjects on two separate occasions at doses between 0.3-30 pmol min(-1). Forearm blood flow was measured using venous occlusion plethysmography...

This receptor family comprises a group of receptors for the calcitonin/CGRP peptides. The calcitonin (CT), amylin (AMY), gene-related peptide (CGRP) and adrenomedullin (AM) (nomenclature as agreed by NC-IUPHAR Subcommittee on CGRP, AM, AMY, CT [131, 74, 71]) are generated genes CALCR (which codes receptor, CTR) CALCRL receptor-like CLR, previously known CRLR). Their function pharmacology altere...

Introduction: The purpose of the present study was to determine whether the novel marker, body adiposity index (BAI), is accurate to measure percentage of body fat (PBF). Materials and methods: Seventy-eight males were undergone anthropometric examination. PBF was calculated by BAI and measured using InBody 3.0.   Results: Significant correlation was found between BAI and PBF (r = 0.751; P < ...

introduction milk solid no-fat is economically very important in cheese industry. compared to the other kinds of milk, ewe’s milk contains higher amount of milk solids no-fat. milk solids no-fat (msnf) contains lactose, caseins, whey proteins, and minerals. the use of test day records in random regression method has several benefits including flexibility to account for the environmental and gen...