نتایج جستجو برای: cgp35348
تعداد نتایج: 66 فیلتر نتایج به سال:
γ-Aminobutyric acid (GABA), which is synthesized by glutamic acid decarboxylase from glutamic acid, is the main inhibitory neurotransmitter and plays a key role in modulating neuronal activity in mammalian central nervous system. Addit ional ly , GABA is considered to be a multifunctional molecule that has different situational functions in some nonneuronal tissues. GABA exerts its actions via ...
.سابقه و هدف: گاما آمینوبوتیریک اسید (گابا)، یکی از نوروترانسمیترهای مهم سیستم عصبی مرکزی است که به عنوان یک مولکول پیام رسان پاراکرین و اتوکرین عمل می کند. متابولیت های استروئیدی طبیعی پروژسترون و کورتیکوسترون با اتصال به گیرنده غشایی گابا A دارای خواص داروهای آرام بخش، خواب آور، ضدافسردگی، ضد تشنج، شل کننده عضلانی و بیهوش کننده می باشند و مغز به عنوان یک اندام استروئیدساز در تولید این استروئی...
Olfactory receptor neurons of the nasal epithelium send their axons, via the olfactory nerve (ON), to the glomeruli of the olfactory bulb (OB), where the axon terminals form glutamatergic synapses with the apical dendrites of mitral and tufted cells, the output cells of the OB, and with juxtaglomerular (JG) interneurons. Many JG cells are GABAergic. Here we show that, despite the absence of con...
Drugs of abuse increase the activity of dopaminergic neurons of the ventral tegmental area (VTA), and output from the VTA is critical for both natural and drug-induced reward and reinforcement. Ethanol and the abused inhalant toluene both enhance VTA neuronal firing, but the mechanisms of this effect is not fully known. In this study, we used extracellular recordings to compare the actions of t...
-Hydroxybutyrate (GHB), a therapeutic for narcolepsy and a drug of abuse, has several mechanisms of action that involve GHB and GABAB receptors, metabolism to GABA, and modulation of dopaminergic signaling. The aim of these studies was to examine the role of GHB and GABAB receptors in the behavioral effects of GHB. Three approaches were used to synthesize GHB analogs that bind selectively to GH...
Urban, Nathaniel N., Darrell A. Henze, and German BarrioM E T H O D S nuevo. Amplification of perforant-path EPSPs in CA3 pyramidal Transverse hippocampal slices (400–500 mm) were prepared cells by LVA calcium and sodium channels. J. Neurophysiol. 80: from 3to 6-wk-old male Sprague-Dawley rats (Aghajanian and 1558–1561, 1998. The perforant path forms a monosynaptic conRasmussen 1989; Urban and ...
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