The management of scarce groundwater resources involves numerous complex challenges, not least developing appropriate allocation limits for extraction and establishing efficient and equitable allocation between competing uses at various interacting scales. Practitioners, lawmakers and scholars continue to struggle with designing water governance approaches that adequately address these challeng...

The GABA(B) receptor agonist baclofen enhances the epileptiform activity induced by 4-aminopyridine (4AP) in juvenile rat hippocampal slices. In this study, we used a similar experimental approach (i.e., field potential, intracellular, and [K+]o recordings in the CA3 area of slices obtained from 15-23-day-old rats) to establish whether antagonizing GABA(B) receptors could exert opposite (presum...

Features represent the characteristics of objects and selecting or synthesizing effective composite features are the key factors to the performance of object recognition. In this paper, we propose a co-evolutionary genetic programming (CGP) approach to learn composite features for object recognition. The motivation for using CGP is to overcome the limitations of human experts who consider only ...

Protein kinase C (PKC) plays a central role in signal transduction pathways that mediate the action of certain growth factors, tumor promoters, and cellular oncogenes. To explore whether PKC might be an appropriate target for the chemotherapy of human brain tumors, cell lines were established from five glioblastomas, one mixed gliosarcoma and glioblastoma, two astrocytomas, and one choroid plex...

The compositions of the major lipids and their constituent fatty acids and fatty aldehydes from cerebral gray matter, white matter, and myelin, spinal cord myelin, and sciatic nerve were determined in a 57 yr old woman who died of Refsum's disease. There were deficiencies of ethanolamine glycerophosphatides (EGP) in gray matter and frontal lobe myelin, and a lipid with the chromatographic prope...

Although hypertrophic cardiomyopathy (HCM) is genetically determined, several other factors, including autonomic dysfunction, may play a role in the phenotypic expression. A recent study using positron emission tomography with [11C]CGP 12177 ([11C]CGP) demonstrated that beta-adrenoceptor (betaAR) density is reduced in HCM and is correlated with disease progression. This present study tested the...

one of the most common methods for production of ultra fine grained materials is severe plastic deformation (spd). in this study, constrained groove pressing (cgp) and high pressure torsion (hpt) processes as effective methods of severe plastic deformation for the strain imposed on the pure copper were used. this paper presents the results of an experimental research, to review the influence of...

Because it is not known whether ejection influences the negative effect of the Ca2+-sensitizing drugs on ventricular relaxation, we extended our previous analysis of stress-dependent relaxation in isovolumic beats to encompass ejecting beats and evaluated the relationships between both the time of onset of relaxation and the rate of relaxation and wall stress in a broader analysis framework. Fu...

BACKGROUND AND AIMS The subtype and species related heterogeneity of beta adrenoceptors prompted a functional reappraisal of these molecular targets of motility inhibition in the human colon. METHODS Relaxation of muscle strips was measured in vitro. RESULTS The following agonists had decreasing relaxing potency (effective concentration range 10(-8)-10(-4) mol/l): (-)isoprenaline (non-selec...