Chronic granulomatous disease (CGD) is a rare hereditary disorder characterized by recurrent life-threatening bacterial and fungal infections. The underlying defect in CGD is an inability of phagocytes to produce reactive oxygen species as a result of defects in NADPH oxidase. Considering that CGD generally affects about 3-4 in 1,000,000 individuals, it is surprising that the prevalence of CGD ...

  Chronic granulomatous disease (CGD) is a rare inherited disorder characterized by inability of phagocytes to generate oxygen radicals needed for intracellular killing of phagocytic microorganisms. We report a 2.5-year-old Iranian female with multiple liver abscesses. She was admitted in surgical ward because of abdominal pain and fever for one month duration that had no response to conventio...

Geochronological databases are powerful tools for characterizing the crustal evolution and age spectra of a region allow comparison with other areas at regional scale. In this contribution, we present Colombian Database (CGD), which contains curated compilation ca. 67,406 individual published U-Th-Pb, K-Ar, Ar-Ar, Rb-Sr, Sm-Nd, Lu-Hf, Fission-track, U-Th-He, Re-Os mineral whole rock ages that r...

We present the design and implementation of CGD, the CryptoGraphic Disk driver. CGD is a pseudo-device driver that sits below the buffer cache, and provides an encrypted view of an underlying raw partition. It was designed with high performance and ease of use in mind. CGD is aimed at laptops, other single-user computers or removable storage, where protection from other concurrent users is not ...

chronic granulomatous disease (cgd) is a rare disorder of phagocytes, predisposes patients to bacterial and fungal infections. the main purpose of this study was to determine the clinical, radiological, pathologicial features, outcome and response to treatment of children with cgd. thirteen patients with cgd, who had been referred to national research institute of tuberculosis and lung disease ...

chronic granulomatous disease (cgd) is an inherited primary immunodeficiency disease which increases the body’ssusceptibility to infections caused by certain bacteria and fungi. cgd is a rare disease, caused by four genes, one type is 1xlinked and the other three are “autosomal recessive”. although clinical presentation is variable, but characteristic featuresare recurrent pneumonia, lymphadeni...

Aspergillus fumigatus is a model fungal pathogen and a common cause of infection in individuals with the primary immunodeficiency chronic granulomatous disease (CGD). Although primarily considered a deficiency of innate immunity, CGD is also linked to dysfunctional T cell reactivity. Both CD4(+) and CD8(+) T cells mediate vaccine-induced protection from experimental aspergillosis, but the molec...

BACKGROUND Granulibacter bethesdensis is a recently described member of the Acetobacteraceae family that has been isolated from patients with chronic granulomatous disease (CGD). Its pathogenesis, environmental reservoir(s), and incidence of infection among CGD patients and the general population are unknown. METHODS Detected antigens were identified by mass spectroscopy after 2-dimensional e...

Chronic granulomatous disease (CGD) is an inherited disorder of the NADPH oxidase complex in which phagocytes are defective in generating superoxide anion and its metabolites. NADPH oxidase activation leads to activation of sequestered neutrophil proteases that mediate host defense. Invasive aspergillosis and other rarer mold diseases are the leading causes of mortality in CGD, reflecting the k...

A case of a child with chronic granulomatous disease (CGD) presenting with recurrent mycobacterial infections and invasive Aspergillus fumigatus disease is described. Genetic analysis confirmed X-linked CGD with a novel mutation in exon 10 of the CYBB gene - the first South African report of genetically confirmed CGD.