Cystic fibrosis (CF) is the most common recessive autosomal disease among Caucasian. Children with CF have benefitted from advances in medical and nutritional treatments, and this can be gleaned from the improvement in the survival of these patients. The increase in the survival rate brought with it the appearance of co-morbidities related to CF. Nowadays cystic fibrosis-related diabetes (CFRD)...

Cystic Fibrosis (CF) is an autosomal recessive disorder caused by mutations in the Transmembrane Conductance Regulator (CFTR) gene. CF-related diabetes (CFRD) one of most prevalent comorbidities CF. Altered glucose homeostasis has been reported CF patients. The mechanism not fully elucidated. Besides consequence pancreatic endocrine dysfunction, we focus on insulin-responsive tissues and transp...

Objectives: Current median survival in the UK 2021 is 51.4 years for females, and 55.3 males. We used mediation analysis to further understanding of causal pathways leading this disparity. Methods: CF Registry data up 2020 investigate extent which difference life expectancy between males females explained by trajectories markers disease progression over course. considered lung health (represent...

Facilitating education and supporting behaviour change in patients with Cystic Fibrosis Related Diabetes (PwCFRD) traditional CF multidisciplinary clinics can be challenging due to their lengthy busy nature. To combat this, a stand-alone CFRD virtual clinic was pioneered, delivering bespoke for PwCFRD who required specialist support, those new diagnosis of CFRD. Education delivered by the team ...

People with cystic fibrosis (CF) who develop related diabetes (CFRD) have accelerated pulmonary decline, increased infection with antibiotic-resistant Pseudomonas aeruginosa and increased pulmonary exacerbations. We have previously shown that glucose concentrations are elevated in airway surface liquid (ASL) of people with CF, particularly in those with CFRD. We therefore explored the hypothese...

BackgroundCystic Fibrosis Related Diabetes (CFRD) is one of the most common non-respiratory complications CF (Cystic Fibrosis). There a lack clinical research to provide guidance on optimal treatment regimens for various subtypes CFRD.Case ReportThis case describes an 18 year old female, diagnosed with in infancy who presented our clinic evaluation possible related diabetes and episodes hypogly...

Cystic fibrosis related diabetes (CFRD) is a rare pathology that combines genetically determined systemicity with damage to the exocrine glands, which leads early manifestations of disease, clear exacerbation and chronicity process, possible complications in bone remodeling occurrence malignant tumors. Purpose - acquaint practitioners peculiarities manifestations, diagnosis course chondroblasti...

Objectives: Insulin deficiency in cystic fibrosis (CF) leads to CF related diabetes (CFRD), and dysregulation of other enteroendocrine hormones may further impair insulin secretion CF. This study investigated whether glucose intolerance was associated with altered incretin or somatostatin adults Methods: We conducted a cross-sectional using multiple-sample oral tolerance tests (OGTTs) at the Co...

C ystic fibrosis–related diabetes (CFRD) is considered the most common comorbidity in patients affected by cystic fibrosis (CF), with a prevalence increasing with age (1). Recently, more attention has been turned to other less severe glucose metabolism derangements (GMD), since prediabetes may be related to increased morbidity (1), and early treatment may improve the clinical course in patients...