Cystic fibrosis (CF) is characterized by inflammatory lung disease that significantly contributes to morbidity and mortality. Airway epithelial cells play a role in the inflammatory signaling in CF and have been reported to exhibit a number of dysfunctions in signaling cascades that modulate inflammation. Previously, we reported that the activity of nuclear factor erythroid-derived-like 2 (Nrf2...

BACKGROUND Several cases of Burkholderia pseudomallei infection in CF have been previously reported. We aimed to identify all cases globally, risk factors for acquisition, clinical consequences, and optimal treatment strategies. METHODS We performed a literature search to identify all published cases of B. pseudomallei infection in CF. In addition we hand-searched respiratory journals, and co...

Airway nitric oxide (NO) is a ubiquitous signaling molecule with bronchoprotective, anti-inflammatory and anti-infective roles. Cystic fibrosis (CF) is a chronic lung condition associated with deceased exhaled NO. Strategies to increase exhaled NO in CF have yielded inconsistent results. A potential new method of increasing systemic NO involves ingestion of dietary, inorganic nitrate which is r...

Heterogeneous cellular networks may be defined by several parameters that determine their performance, being known as the Key Performance Indicators (KPIs).. In order to guarantee a desired Quality of Service (QoS) a proper balance of these parameters is required. An approach to integrate a set of KPIs into a single one, is presented by using a Cost Function (CF). The CF takes these KPIs into a...

There are no wholly successful chemotherapeutic strategies against Burkholderia cepacia complex (BCC) colonization in cystic fibrosis (CF). We assessed the impact of cysteamine (Lynovex) in combination with standard-of-care CF antibiotics in vitro against BCC CF isolates by the concentration at which 100% of bacteria were killed (MIC100) and checkerboard assays under CLSI standard conditions. C...

One of the major goals of the Sustainable Agriculture Farming initiatives at UC Davis is to provide information about the feasibility of adopting conservation tillage and cover cropping at the farm level. The project includes two tillage schemes: standard tillage (ST) and conservation tillage (CT), and three farming methods: conventional, organic, and winter legume cover crop. All three product...

Global biodiversity continues along a trajectory of decline despite enormous conservation efforts (Rands et al., 2010). This is also true in China, one of the most biodiversity-rich countries in the world (Liu and Raven, 2010; Ministry of Environmental Protection of China, 2010a). To fundamentally change this trajectory, it is essential to understand complex interactions among various forces af...

Advances in the treatment and life expectancy of cystic fibrosis (CF) patients mean that motherhood is now a realistic option for many women with CF. This qualitative study explored the psychosocial impact and adjustments made when women with CF become mothers. Women with CF (n = 11) were recruited via an online forum and participated in semistructured telephone interviews about their experienc...