نتایج جستجو برای: cetp

تعداد نتایج: 1082  

2016
Kinta Hatakeyama

CETP is a hydrophobic glycoprotein secreted by the liver and is predominantly associated with apo A-I containing lipoproteins in the plasm. CETP plays important roles in modulating vascular lipoproteins. It facilitates the redistribution of cholesterol esters, phospholipids, and triglycerides between plasma lipoproteins. As a consequence of CETP-mediated transfer of cholesterol esters from HDL(...

2013
M. J. Graham R. G. Lee A. E. Mullick W. Fu D. Norris

Journal of Lipid Research Volume 54, 2013 2647 Copyright © 2013 by the American Society for Biochemistry and Molecular Biology, Inc. of agents that increase levels of HDL-C has been challenging, cholesteryl ester transfer protein (CETP) has emerged as a potential therapeutic target. In human plasma, CETP facilitates the movement of neutral lipid between lipoproteins, resulting in a net exchange...

Journal: :The Journal of biological chemistry 1991
X C Jiang P Moulin E Quinet I J Goldberg L K Yacoub L B Agellon D Compton R Schnitzer-Polokoff A R Tall

The plasma cholesteryl ester transfer protein (CETP) catalyzes the transfer of cholesteryl esters from high density lipoproteins (HDL) to triglyceride-rich lipoproteins and plays a major role in the catabolism of HDL. Lipoprotein lipase (LPL) is the rate-limiting enzyme for hydrolysis of circulating triglyceride and is involved in HDL formation. We show that tissues containing LPL are major sou...

Journal: :Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2007
Y Inukai K Ito K Hara A Yamazaki K Takebayashi Y Aso T Inukai

OBJECTIVE To investigate the role of serum cholesterol ester transfer protein (CETP) and the metabolism of various lipids including apoproteins in patients with type 2 diabetes. MATERIALS AND METHODS The relationships between serum concentrations of CETP and various lipids and apoproteins were investigated in 193 patients with type 2 diabetes mellitus and 68 age-matched healthy subjects. Seru...

2000
Shizuya Yamashita Takao Maruyama Ken-ichi Hirano Naohiko Sakai Norimichi Nakajima Yuji Matsuzawa

Hyperalphalipoproteinemia (HALP) is caused by a variety of genetic and environmental factors. Among these, plasma cholesteryl ester transfer protein (CETP) deficiency is the most important and frequent cause of HALP in the Asian populations. CETP facilitates the transfer of cholesteryl ester (CE) from high density lipoprotein (HDL) to apolipoprotein (apo) B-containing lipoproteins, and is a key...

2014
Tarja Äijänen Artturi Koivuniemi Matti Javanainen Sami Rissanen Tomasz Róg Ilpo Vattulainen

Cholesteryl ester transfer protein (CETP) mediates the reciprocal transfer of neutral lipids (cholesteryl esters, triglycerides) and phospholipids between different lipoprotein fractions in human blood plasma. A novel molecular agent known as anacetrapib has been shown to inhibit CETP activity and thereby raise high density lipoprotein (HDL)-cholesterol and decrease low density lipoprotein (LDL...

Journal: :Journal of lipid research 2007
Wim A van der Steeg G Kees Hovingh Anke H E M Klerkx Barbara A Hutten Inge C Nootenboom Johannes H M Levels Arie van Tol Gees M Dallinga-Thie Aeilko H Zwinderman John J P Kastelein Jan Albert Kuivenhoven

It is unclear whether cholesteryl ester transfer protein (CETP) contributes to high density lipoprotein cholesterol (HDL-C) levels in hyperalphalipoproteinemia (HALP) in Caucasians. Moreover, even less is known about the effects of hereditary CETP deficiency in non-Japanese. We studied 95 unrelated Caucasian individuals with HALP. No correlations between CETP concentration or activity and HDL-C...

Journal: :The Journal of clinical investigation 1994
S Zhong I J Goldberg C Bruce E Rubin J L Breslow A Tall

The plasma cholesteryl ester transfer protein (CETP) mediates the exchange of HDL cholesteryl esters with triglycerides of other lipoproteins. Subsequent lipolysis of the triglyceride-enriched HDL by hepatic lipase leads to reductions of HDL size and apoA-I content. To investigate a possible modulation of the effects of CETP by apoA-II, human CETP transgenic mice were cross-bred with transgenic...

Journal: :Nutrition & Metabolism 2005
Pujitha P de Silva Alka Agarwal-Mawal Phillip J Davis Sukhinder Kaur Cheema

BACKGROUND: Cholesterol ester transfer protein (CETP) plays a major role in regulating the levels of LDL- and HDL-cholesterol. We previously observed a fish-oil-induced elevation of low-density lipoprotein (LDL)-and very-low-density lipoprotein (VLDL)-cholesterol concentrations and a decrease in high-density lipoprotein (HDL)-cholesterol concentration in F1B hamsters. The molecular mechanism/s ...

Journal: :Annual review of biochemistry 1986
A R Tall

The plasma lipid transfer proteins mediate the transfer and exchange of phospholipids and neutral lipids between the plasma lipoproteins. The cholesteryl ester transfer protein (CETP) and the phospholipid transfer protein (PLTP) are members of the lipid transfer/lipopolysaccharide binding gene family. The CETP contains binding sites for cholesteryl ester and triglycerides and probably acts by a...

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