Several experiments reported in the preceding paper (1) have indicated that not all the copper atoms of human ceruloplasmin are present in the same state within this molecule. Furthermore, acid-base titrations of ceruloplasmin have shown distinct regions of instability. The absorbancy changes noted in the 610-rnp range during these titrations indicated the involvement of the chromophoric copper...

A method is described for automated measurement of serum ceruloplasmin ferroxidase activity. In this method, Fe2+ ions are used as the substrate. In addition, a new calibration system without ceruloplasmin is also presented. Optimum assay reaction conditions were determined. Maximal catalytic activity was obtained at 0.45 mol/L acetate buffer, pH 5.8. The reagents and calibrator are stable for ...

Electron spin resonance (ESR) analysis plus chemical determinations show that the predominant ESR signals seen in frozen solutions of human plasma are due to the copper protein ceruloplasmin. The elevation of ceruloplasmin con centration above normal values in pathological processes is positively correlated with the increased ESR signal height seen in patients with cancer, infections, and myoca...

The research included Estimation of some biochemical parameters like Hepcidin hormone , parathyroid hormone, vitamin D3 ,iron ,calcium, total cholesterol, triglycerides, HDL, VLDL, paraoxonase, glutathione-s-transferase, BMI ,and ceruloplasmin in serum women with osteoporosis after menopausal, the results shewed a decrease levels (Hepcidin D, calcium, hemoglobin, BMI, and albumin) blood patient...

Acute graft-versus-host-disease (aGvHD) is the major cause of non-relapse mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recently, diagnostic biomarkers for aGvHD have been shown to play important roles in evaluating disease status and mortality risk after allo-HSCT. To identify plasma biomarkers for aGvHD with high sensitivity and specificity, a quantitative pr...

In vivo and post-mortem studies have demonstrated that increased nigral iron content in patients with Parkinson's disease is a prominent pathophysiological feature. However, the mechanism and risk factors associated with nigral iron deposition in patients with Parkinson's disease have not been identified and represent a key challenge in understanding its pathogenesis and for its diagnosis. In t...

Ceruloplasmin is an abundant alpha 2-serum glycoprotein that contains 95% of the copper found in the plasma of vertebrate species. We report here on the identification of a genetic defect in the ceruloplasmin gene in a patient previously noted to have a total absence of circulating serum ceruloplasmin in association with late-onset retinal and basal ganglia degeneration. In this patient T2 (tra...

Serum copper and ceruloplasmin concentrations were determined in 180 normal male subjects and 44 female subjects, age 20 to 89 years. A small but significant increase (p < .025) in serum copper concentrations was observed with age in the male population; none was observed in the females. Serum ceruloplasmin concentrations failed to change with age in either group. In contrast with most previous...

Background The known functions of ceruloplasmin oxidase activity (COA) include copper transportation, iron metabolism, antioxidant defense and involvement in angiogenesis and coagulation. The role of ceruloplasmin oxidase involving the interaction of oxidant and anti-oxidant balance in allergic diseases is still unknown. It was previously reported that synthesis of ceruloplasmin was situmulated...

Oxygen free radicals play an important role in the pathogenesis of tissue damage in many pathological conditions, including liver diseases. The present study aims to investigate the possible relationship between serum malondialdehyde level, an index of lipid peroxidation, and ceruloplasmin level, a protective agent against lipid peroxidation, in chronic liver disease. A total of 65 consecutive ...