BACKGROUND Although the frequency for the use of moderate hypothermia in acute ischemic stroke is increasing, the optimal acid-base management during hypothermia remains unclear. This study investigates the effect of pH- and alpha-stat acid-base management on cerebral blood flow (CBF), infarct volume, and cerebral edema in a model of transient focal cerebral ischemia in rats. METHODS Twenty S...

Background: Decompressive craniectomy is an effective treatment for malignant middle cerebral artery (MCA) territory infarct. But the age limit surgery not well defined. The time window of considered less than 96 hours.Methods: This retrospective study 60 patients MCA infarct who underwent decompressive selected in this and using modified Rankin score.Results: In 36 were years above years. 38 r...

Background and Purpose—Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke. Methods—We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice. Results—Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcome af...

BACKGROUND AND PURPOSE We tested the hypothesis that fructose-1,6-bisphosphate, when administered 10 minutes before the end of 2 hours of reversible middle cerebral artery occlusion, reduces ischemia-reperfusion injury and infarct volume measured after a 3-day survival period in rats. METHODS After 1 hour and 50 minutes of middle cerebral artery occlusion by the intraluminal suture method, fr...

The methionine analogue methionine sulfoximine was administered to 10 rats 24 hours before occlusion of the proximal left middle cerebral artery. Three days later the rats were decapitated and the brain infarct volumes were compared with those in 10 control rats that received saline before middle cerebral artery occlusion. The mean volume of the infarct in the cerebral cortex was reduced by 33%...