The auditory brainstem response (ABR) test provides information about the inner ear (cochlea) and the central pathways for hearing. The ABR reflects the electrical responses of both the cochlear ganglion neurons and the nuclei of the central auditory pathway to sound stimulation (Zhou et al., 2006; Burkard et al., 2007). The ABR contains 5 identifiable wave forms, labeled as I-V. Wave I represe...

The auditory thalamic area includes the medial geniculate body (MGB) and the lateral part of the posterior thalamic nucleus (Pol). The MGB can be subdivided into a ventral subdivision, forming part of the lemniscal (primary) auditory pathway, and medial and dorsal subdivisions, traditionally considered (alongside the Pol) part of the non-lemniscal (secondary) pathway. However, physiological stu...

Processing of short frequency modulated (FM) sweeps has not been extensively studied in the central auditory system. Here we report the neural representations of oneoctave FM sounds along three centers of the auditory pathway: thalamus, primary auditory cortex (A1) and posterior auditory field (PAF). Dense microelectrode mapping techniques were used to collect multiunit responses from 249 sites...

Tinnitus and hyperacusis are common and potentially serious hearing disorders associated with noise-, age- or drug-induced hearing loss. Accumulating evidence suggests that tinnitus and hyperacusis are linked to excessive neural activity in a distributed brain network that not only includes the central auditory pathway, but also brain regions involved in arousal, emotion, stress and motor contr...

Age-related hearing loss (ARHL) is marked by audiometric hearing deficits that propagate along the auditory pathway. Neurochemical changes as a function of aging have also been identified in neurons along the auditory pathway in both rodents and carnivores, however, very little is known about how these neurochemicals change in the non-human primate. To examine how these compensatory neurochemic...

BACKGROUND Tinnitus is an important occupational health concern, but few studies have focused on the central auditory pathways of workers with a history of occupational noise exposure. Thus, we analyzed the central auditory pathways of workers with a history of occupational noise exposure who had normal hearing threshold, and compared middle latency auditory evoked potential in those with and w...

BACKGROUND AND PURPOSE Auditory functional limitations experienced by patients after stroke of the central auditory pathways remain underinvestigated. Purpose- To measure patient-reported hearing difficulties in everyday life in nonaphasic patients with stroke of the auditory brain versus normal control subjects. To examine how hearing difficulties correlate with auditory tests and site of lesi...

background and aim: auditory processing disorders may have detrimental consequences on a child’s life, if undiagnosed and untreated. the multiple auditory processing assessment (mapa), as a valid model, has been introduced for central auditory processing assessment and diagnosis in school children. the purpose of this study was to design and evaluate the persian version of mapa for auditory pro...

Canavan Disease (CD) is a leukodystrophy caused by homozygous null mutations in the gene encoding aspartoacylase (ASPA). ASPA-deficiency is characterized by severe psychomotor retardation, and excessive levels of the ASPA substrate N-acetylaspartate (NAA). ASPA is an oligodendrocyte marker and it is believed that CD has a central etiology. However, ASPA is also expressed by Schwann cells and AS...