We have analyzed the blood B cell subpopulations of children with systemic lupus erythematosus (SLE) and healthy controls. We found that the normal recirculating mature B cell pool is composed of four subsets: conventional naive and memory B cells, a novel B cell subset with pregerminal center phenotype (IgD(+)CD38(+)centerin(+)), and a plasma cell precursor subset (CD20(-)CD19(+/low)CD27(+/++)...

In this paper, we prove that if E is an uniquely remotal subset of a real normed linear space such has Chebyshev center c ∈ and the farthest point map F : → restricted to [c, (c)] p...

Although CD4+ T cells form a major subset of TCRab T cells, only a small number of TCRgd T cells express CD4. Factors contributing to the down-regulation of CD4+ TCRgd T cells have not been identi®ed. The CD5 molecule is expressed on most TCRgd T cells in the spleen, whereas only a few intestinal intraepithelial TCRgd T cells express this molecule in wild-type mice and TCRb mutant (b±/±) mice. ...

We have recently demonstrated that a novel somatically mutated B220(-) memory B cell subset rapidly dominates the secondary immune response to (4-hydroxy-3-nitrophenyl) acetyl (NP). Upon adoptive transfer with Ag, B220(+)NP(+) memory B cells produce large numbers of B220(-)NP(+) B cells that can rapidly differentiate into plasma cells. Therefore, it is not clear whether the novel B220(-) memory...

The spatial arrangement of a chemical compound plays an important role regarding the related properties or activities. A straightforward approach to encode the geometry is to enumerate pairwise spatial relationships between k substructures, like functional groups or subgraphs. This leads to a combinatorial explosion with the number of features of interest and redundant information. The goal of ...

Given a metric (U, d) with |U | = n, a subset S ⊆ U with |S| = l, a non-negative function w : U → <, and an integer k ≤ l, the generalized static k-center and k-median problems ask to pick a subset X ⊆ S with |X| = k so as to minimize maxx∈U d(x,X) and ∑ x∈U d(x,X) · w(x), respectively, where d(x,X) = miny∈X d(x, y). Each point in X is called a center and each point in U is assigned to its clos...

Our system consists of a center and a set, U of n users. The center provides keys to the users when they join the system. Later on, the center wants to broadcast an encrypted message (such as the password to view “Matrix”) which can be deciphered only by a dynamically changing privileged subset of users, T , i.e., the non-privileged users should not be able to learn the message. To achieve this...

Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma. Although many investigations have been performed on the prognostic factors of DLBCL, no reports have focused on localized nodal DLBCL. We examined the prognostic significance of 39 Japanese patients with localized nodal DLBCL with special reference to the germinal center B-cell-like (GCB) versus non-germina...

Recently we have identified subgroups of de novo primary diffuse large B-cell lymphoma (DLBCL) based on complementary DNA microarray-generated gene expression profiles. To correlate the gene expression profiles with cytogenetic abnormalities in these DLBCLs, we examined the occurrence of the t(14;18)(q32;q21) in the 2 distinctive subgroups of DLBCL: one with the germinal center B-cell gene expr...