The establishment and maintenance of characteristic cellular morphology is especially important in the nervous system, in which neurons make connections with specific targets, thereby enabling the processing of information. The axonal pattern is crucial in determining the target cells, and is controlled by extracellular molecules, called axon guidance molecules. In culture, isolated neurons are...

The role of the basal lamina in maintaining the normal morphology of mouse embryo submandibular epithelia was assessed by examining its production as well as the cellular and organ culture changes associated with its removal and replacement. The lamina was removed from epithelia isolated free of mesenchyme by brief treatment with testicular hyaluronidase in the absence of calcium. The treatment...

the characteristics of cellular and molecular mechanisms associated with cell proliferation and differentiation is important to understand malignancy. in this report we characterise a leukemic model, d5a1, to study the action of differentiation agent, cellular events and gene expression of the selected transcription factors. cells induced with 4 mm hexamethylene bisacetamide (hmba) caused signs...

Photodynamic therapy (PDT) is phototherapeutic modality used in the treatment of neoplastic and non-neoplastic diseases. The photochemical interaction of light, photosensitizer (PS) and molecular oxygen produces singlet oxygen which induces cell death. Zinc sulfophthalocyanine (ZnPcSmix) has been shown to be effective in A549 monolayers, multicellular tumor spheroids (MCTSs) (250 µm) and not on...

Incubation of neutrophils with cytokines such as granulocyte macrophage colony-stimulating factor (GM-CSF) delays their loss of function and changes in cellular morphology that are characteristic of apoptosis. Adenosine triphosphate (ATP) and the diadenosine polyphosphates Ap,A and Ap,A were almost as effective as GM-CSF in delaying neutrophil apoptosis. The nucleotides could thus preserve cell...

objectives: osteoblasts are the most important cells in the osseointegration process. despite years of study on dental implants, limited studies have discussed the effect of saliva on the adhesion process of osteoblasts to implant surfaces. the aim of this in vitro study was to evaluate the effect of saliva on morphology and differentiation of osteoblasts attached to implant surfaces. materials...

the purpose of this research was to investigate the effect of mir-429 ectopic over-expression on u251 glioblastoma cell line. it has been shown that mir-429 could target bmk1 and reduce glioma cells invasion. we cultured u251-mir-429 cells and observed changes in their morphology for 14 days. they seemed to become wider with expanded cytoplasm and go on differentiation. neuronal (nefm, nse and ...

We have adapted METRONAMICA, an established cellular automata (CA) modelling system, to simulate the historical growth of a section of a large world city. Our model is tuned to reflect the morphology of land use patterns more accurately than traditional CA models, which abstract those patterns to more aggregate spatial scales. We explore the spatial determinants of land use patterns with detail...

The characteristics of cellular and molecular mechanisms associated with cell proliferation and differentiation is important to understand malignancy. In this report we characterise a leukemic model, D5A1, to study the action of differentiation agent, cellular events and gene expression of the selected transcription factors. Cells induced with 4 mM hexamethylene bisacetamide (HMBA) caused signs...