background: tuberculosis (tb) remains an important health problem throughout the world. despite its significance in public health, mechanisms of protective immunity against mycobacyerium tuberculosis in humans have not yet been understood. objective: to evaluate cell mediated immune response against purified ag 85, ppd and phytohemagglutinin (pha) in patients with tuberculosis and healthy tuber...

memory formation is the most important aspect of a vaccine which can guarantee long-lasting immunity and protection. the main aim of the present study was to evaluate the memory immune responses after immunization with a mini vaccine. mice were immunized with human immunodeficiency virus-1 p24-nef fusion peptide and then cellular and humoral immune responses were evaluated. in order to determin...

this study was conducted to investigate the effects of curcuma zedoaria and zingiber zerumbet on non-specific immune responses of grouper (epinephelus coioides). fish were fed an experimental diet containing 0, 0.5, 1.0, 2.5 g/kg of c. zedoaria and z. zerumbet mixed diets twice daily for two weeks. non-specific immune parameters such as respiratory burst activity, reactive oxygen species, phago...

one of the most common outcomes of pulp inflammation is periapical granuloma formation. existence of immune cells in these lesions showed involvement of both humoral and cellular immunity in the site. the presence of different antigens in the root canal causes production o various antibodies and consequent immunological reactions. different theories have been proposed on periapical cysts. the m...

Background & Aims: Dry type localized cutaneous Leishmaniasis due to Leishmania tropica is one of the most prevalent cutaneous parasitic infections in Kerman province. It seems that cellular immune response and the nature of immune inflammatory cells comprising the inflammatory background play a determinant role in this infection. Methods: Skin biopsies of 53 patients with acute(<2 years durati...

objective: hepatitis c virus (hcv) is one of the most relevant persistent infections afflicting the human population. control of viral replication in hcv infection has been associated with the cellular component of the host immune response. several mechanisms have been proposed to explain this abnormal immune response, among them an altered activity of regulatory t cells (tregs) being the most ...

objective: hypericum perforatum (st. john&apos;s wort) has long been used in traditional medicine to treat a variety of internal and external ailments. the present study was done to evaluate the immumodulatory potentials of the hydroalcoholic extract of h. perforatum. materials and methods: twenty male balb/c-mice were randomly allocated in two equal groups and immunized with sheep red blood ce...

Cell suspensions from the spleens of normal mice or mice injected with sheep erythrocytes were separated on a discontinous bovine serum albumin density gradient. Four bands or subpopulations were obtained and were assayed for antibody-forming cells, and for antigen-sensitive precursor cells. The antibody-forming cells were assayed by the hemolytic plaque assay and the antigen-sensitive precurso...

conclusions in conclusion, pegfp-kmp-gp96 (fusion) induced th1 platform immune response against leishmania major (mrho/ir/75/er) infection. results according to the results, the level of cytokines interferon-gamma (ifn-γ) and interleukin (il)-4, and ratio of ifn-γ /il4 was changed among different groups of mice before and seven weeks after immunization. the cytokines were increased significantl...

background: cutaneous leishmaniasis is an endemic disease in many regions of iran, including the city of mashhad. in recent years, some cases have not responded to glucantime, the usual treatment for this disease. the cellular immune response caused by t-helper type 1 (th1) cells has an important role in protection against leishmaniasis, and activation of the t-helper type 2 (th2) response caus...