Extracts of the medicinal plant St. John's wort (Hypericum perforatum) are widely used for the treatment of mild to moderate depression. Hyperforin, a constituent of St. John's wort, is known to inhibit the sodium-dependent uptake of catecholamines and amino acids into synaptic nerve endings, probably by interference with mechanisms controlling the synaptic sodium concentration. Because de novo...

BACKGROUND Recent investigations suggest an anti-inflammatory and antibacterial effect of hyperforin, which is a major constituent of Hypericum perforatum L. (Saint John's wort). OBJECTIVE In the present half-side comparison study we assessed the efficacy of a cream containing Hypericum: extract standardised to 1.5% hyperforin (verum) in comparison to the corresponding vehicle (placebo) for t...

This special issue on the genus Hypericum (family Hypericaceae) consists of 12 articles focusing on recent advancements related to biosynthetic pathways, biotechnology, molecular biology, genomics, pharmacology, and related disciplines. Hypericum is well-known for its medicinal properties. There are about 487 Hypericum spp., which are distributed across every continent except Antarctica. Althou...

Extracts of the medicinal plant St. John's wort (Hypericum perforatum) are widely used for the treatment of affective disorders. Hyperforin, a constituent of St. John's wort, is known to modulate the release and re-uptake of various neurotransmitters, an action that likely underlies its antidepressive activity. We now report that hyperforin also has N-methyl-D-aspartate (NMDA)-antagonistic effe...

Fungal elicitor prepared from the cell walls of Aspergillum niger induces multiple responses of Hypericum perforatum cells, including nitric oxide (NO) generation, jasmonic acid (JA) biosynthesis, and hypericin production. To determine the role of NO and JA in elicitor-induced hypericin production, we study the effects of NO scavenger 2- to 4-carboxyphenyl-4,4, 5,5-tetramethylimidazoline-1-oxyl...

BACKGROUND Mood and anxiety disorders pose significant health burdens on the community. Kava and St. John's wort (SJW) are the most commonly used herbal medicines in the treatment of anxiety and depressive disorders, respectively. OBJECTIVES The objective of this study was to conduct a comprehensive review of kava and SJW, to review any evidence of efficacy, mode of action, pharmacokinetics, ...

St John’s Wort (SJW, Hypericum perforatum), a popular dietary supplement is immensely used in treating a broad range of psychiatric disorders. It is reported to possess both favorable and detrimental effects. Which are attributed to the active principles (hypericin and hyperforin) of SJW. Nevertheless, there is dearth of reports on toxicity of SJW. In view of the traditional significance of SJW...

Hyperforin is an important active component of St. John's wort (Hypericum perforatum) that has been suggested to be responsible for the St. John's wort antidepressive effects and herbal-drug interactions. In this study, the in vitro metabolism profile of hyperforin was investigated using liver microsomes from male and female Sprague-Dawley rats, with or without induction by phenobarbital or dex...

The intention of this research is qualitative and quantitative study of Hypericum perforatum's products. The main use of this plant is for treatment of depression. Furthermore, it has anti-inflammatory, antispasmodic, antivirus, sedative and anti-migraine activities. Hypericin, which is one of the effective compounds of this plant, has antidepressant effect and it has been evaluated in this res...

The intention of this research is qualitative and quantitative study of Hypericum perforatum's products. The main use of this plant is for treatment of depression. Furthermore, it has anti-inflammatory, antispasmodic, antivirus, sedative and anti-migraine activities. Hypericin, which is one of the effective compounds of this plant, has antidepressant effect and it has been evaluated in this res...