dynamic cellular manufacturing systems,   mixed-integer non-linear programming,   production planning, manufacturing attributes   this paper presents a novel mixed-integer non-linear programming model for the design of a dynamic cellular manufacturing system (dcms) based on production planning (pp) decisions and several manufacturing attributes. such an integrated dcms model with an extensive c...

the present study was designed to explore the anti-inflammatory effect of fluvoxamine, as a selective serotonin reuptake inhibitor (ssri) anti-depressant, on carrageenan-induced paw edema in more details. at first, fluvoxamine was administered intra-peritoneally (2.5, 12.5, 25 and 50 mg kg-1) 30 min before the subplantar injection of carrageenan. fluvoxamine was also injected intra-peritoneally...

primary non-hodgkin’s lymphoma of the cranial vault is extremely rare. this case report presents a 42-year-old man with a painless subcutaneous scalp mass which extended intracranially associated with recent mild headache. initial computed tomography and magnetic resonance imaging revealed two lesions emanating from the skull. biopsy revealed a diagnosis of diffuse large b cell lymphoma (dlbcl)...

The population of cells that make up a cancer are manifestly heterogeneous at the genetic, epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human malignancies, review the mechanisms that are responsible for generating and maintaining ITH, and discuss the ramifications and opportunities that ITH presents for cancer prognos...

melissa officinalis l. is a medicinal plant with a large variety of pharmacological effects and traditional applications. this study aimed to evaluate the protective and antioxidant activities of the extract of m. officinalis aerial parts on human umbilical vein endothelial cells (huvecs) under oxidative stress induced by h 2 o 2 . cells were incubated with h 2 o 2 (0.5 mm, 2 h) after pretreatm...

Breast cancer tissues include carcinoma cells and stromal cells, intra-tumoral stroma that consists of different types cells. For this point, cell-cell interaction communication have a potential role in progression. Mono-cell culture is used for treatment approaches. However, can not be evaluated on mono-culture So, co-culture models provide low-cost screening to determine cell proliferation dr...

Colchicine, a potent neurotoxin derived from plants, has been recently introduced as a degenerative toxin of small pyramidal cells in the cortical area 1 of the hippocampus (CA1). In this study, the effect of the alkaloid in CA1 on the behaviors in the conditioning task was measured. Injections of colchicine (1,5 μg/rat, intra-CA1) was performed in the male Wistar rats, while the animals were s...

Intra-cell travel is a difficult topic in zone-based demand models. In the past, different strategies were applied to approximate average intra-cell distances by using zone size, diameter, neighbors and other techniques. this work we examine new approach which uses address coordinates high performance routing program achieve more accurate results. We apply our method three zoning schemes for ci...


 In mobile networks, such as fifth generation (5G), the appealing characteristics of small cells, like easy deployment, affordable, and low power usage, have led to improvement Heterogeneous Network (HetNet) technique. HetNet, restricted resources are usually shared by that in turns results an interference issue challenges. The latter may be regarded main barrier for appropriate HetNet pe...

Background: Autoimmune type 1 diabetes mellitus is caused by T-cell mediated immune destruction of the insulin-producing β-cell in pancreatic islets of Langerhans. Specificity of the auto-antibodies and of the auto-reactive T-cells has been investigated, in which several auto-antigens were proposed. Objective: To determine whether glutamic acid decarboxylase (GAD) feeding would induce oral tol...