نتایج جستجو برای: cd20

تعداد نتایج: 4923  

Journal: :Blood 2011
Veronika Bachanova Karamjeet Sandhu Sophia Yohe Qing Cao Michael J Burke Michael R Verneris Daniel Weisdorf

CD20 expression is associated with early recurrence and inferior survival in precursor-B acute lymphoblastic leukemia patients treated with chemotherapy. Whether CD20 influences outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is unknown. We analyzed CD20 expression on blasts at diagnosis in 157 patients who underwent allo-HSCT in the first complete remission (57%) ...

Journal: :American journal of clinical pathology 2003
Julio Delgado Estella Matutes Alison M Morilla Ricardo M Morilla Kwasi A Owusu-Ankomah Furheen Rafiq-Mohammed Ilaria del Giudice Daniel Catovsky

We analyzed by flow cytometry the expression of CD20 and FMC7 in cell suspensions from 932 patients, including 630 cases of chronic lymphocytic leukemia (CLL), 23 cases of other B-cell leukemias, and 279 cases of B-cell non-Hodgkin lymphoma (B-cell NHL). CD20 was positive in 94.5% of cases; FMC7 was positive in 35.7%. There was a correlation between CD20 and FMC7 expression in patients with B-c...

Journal: :The Journal of clinical investigation 2010
Taco W Kuijpers Richard J Bende Paul A Baars Annette Grummels Ingrid A M Derks Koert M Dolman Tim Beaumont Thomas F Tedder Carel J M van Noesel Eric Eldering René A W van Lier

CD20 was the first B cell differentiation antigen identified, and CD20-specific mAbs are commonly used for the treatment of B cell malignancies and autoantibody-mediated autoimmune diseases. Despite this the role of CD20 in human B cell physiology has remained elusive. We describe here a juvenile patient with CD20 deficiency due to a homozygous mutation in a splice junction of the CD20 gene (al...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Che-Leung Law Charles G Cerveny Kristine A Gordon Kerry Klussman Bruce J Mixan Dana F Chace Damon L Meyer Svetlana O Doronina Clay B Siegall Joseph A Francisco Peter D Senter Alan F Wahl

The anti-CD20 antibody rituximab is useful in the treatment of certain B-cell malignancies, most notably non-Hodgkin's lymphoma. Its efficacy has been increased when used in combination with chemotherapy, yet anti-CD20 monoclonal antibodies (mAbs) directly conjugated with drugs such as doxorubicin (Dox) have failed to deliver drug or to demonstrate antitumor activity. We have produced anti-CD20...

2017
Annarita Scialdone Muhammad Sharif Hasni Jesper Kofoed Damm Andreas Lennartsson Urban Gullberg Kristina Drott

Treatment with anti-CD20 antibodies is only moderately efficient in chronic lymphocytic leukemia (CLL), a feature which has been explained by the inherently low CD20 expression in CLL. It has been shown that CD20 is epigenetically regulated and that histone deacetylase inhibitors (HDACis) can increase CD20 expression in vitro in CLL. To assess whether HDACis can upregulate CD20 also in vivo in ...

2011
Alexandrine Geffroy-Luseau David Chiron Géraldine Descamps Gaëtan Jégo Martine Amiot Catherine Pellat-Deceunynck

Plasma cells (PCs) have a heterogeneous phenotype in humans. While bone marrow PCs are CD20-CD138+, tonsil PCs are CD20+CD138+/- and peripheral plasmablasts (PBs) are CD20-CD138-. In vitro, PCs are mainly generated by the activation of CD27+ memory B-cells through transient stimulation of CD40, and their phenotype appears similar to that of bone marrow PCs. While CD20 expression is lost at the ...

Journal: :Haematologica 2012
Francesco Mannelli Giacomo Gianfaldoni Tamara Intermesoli Chiara Cattaneo Erika Borlenghi Sergio Cortelazzo Irene Cavattoni Enrico Maria Pogliani Monica Fumagalli Emanuele Angelucci Claudio Romani Fabio Ciceri Consuelo Corti Anna Scattolin Agostino Cortelezzi Daniele Mattei Ernesta Audisio Orietta Spinelli Elena Oldani Alberto Bosi Alessandro Rambaldi Renato Bassan

The prognostic significance of CD20 expression in acute lymphoblastic leukemia has been investigated in children and adults but is still a subject of debate. The aim of our study was to correlate CD20 expression with clinical-biological characteristics and outcome in 172 Philadelphia chromosome negative patients prospectively treated in a multicenter trial introducing the molecular evaluation o...

Journal: :Journal of immunology 2014
Arumugam Palanichamy Sarah Jahn Dorothee Nickles Mia Derstine Aya Abounasr Stephen L Hauser Sergio E Baranzini David Leppert H-Christian von Büdingen

In multiple sclerosis (MS), B cell-depleting therapy using monoclonal anti-CD20 Abs, including rituximab (RTX) and ocrelizumab, effectively reduces disease activity. Based on indirect evidence, it is generally believed that elimination of the Ag-presenting capabilities and Ag nonspecific immune functions of B cells underlie the therapeutic efficacy. However, a small subset of T lymphocytes (T c...

Journal: :The Journal of biological chemistry 2008
Maria J Polyak Haidong Li Neda Shariat Julie P Deans

B cell antigen receptor (BCR) signaling initiates sustained cellular calcium influx necessary for the development, differentiation, and activation of B lymphocytes. CD20 is a B cell-restricted tetraspanning protein organized in the plasma membrane as multimeric molecular complexes involved in BCR-activated calcium entry. Using coprecipitation of native CD20 with tagged or truncated forms of the...

Journal: :Blood 2005
Stephen D Gillies Yan Lan Steven Williams Frank Carr Stephen Forman Andrew Raubitschek Kin-Ming Lo

We have engineered an anti-CD20-interleukin 2 (IL-2) immunocytokine (ICK) based on the Leu16 anti-CD20 antibody and have deimmunized both the variable (V) regions as well as the junction between the heavy (H) chain constant region and IL-2. Mutations were made to remove potential T-cell epitopes identified by in silico binding to major histocompatibility complex (MHC) class II molecules. The re...

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