OBJECTIVE Given the magnitude of the HIV epidemic infection, many viral and human factors were analyzed, and the most decisive was the variant CCR5-Δ32. The presence of a low HIV prevalence (1.8%) in Gabon in the 1990s, compared to neighboring countries, represents a paradox that led us to search for viral and human genetic variants in this country. In this study, only variants of coreceptors a...

Receptor Tyrosine kinases (RTKs) play a crucial role in the signal transduction pathways at cellular levels. RTK plays vital communication and transmission of signals to adjacent cells regulates different functions cell, such as growth, differentiation, metabolism motility. s triggers growth factor receptors epidermal factor, insulin factor-1 receptor, platelet derived fibro blast receptor vasc...

We report the onset of euglycemic diabetic ketoacidosis (EDKA) in a 20-year-old male patient with new-onset type 2 diabetes mellitus (T2DM) 5 days after initiation diet restriction and combination SGLT2 (sodium–glucose co-transporter 2) inhibitors, glucagon-like peptide 1 receptor agonists, metformin. The use inhibitors symptomatic patients T2DM along extreme reduction carbohydrate intake might...

The beta-chemokine receptor CCR5 is considered to be an attractive target for inhibition of macrophage-tropic (CCR5-using or R5) HIV-1 replication because individuals having a nonfunctional receptor (a homozygous 32-bp deletion in the CCR5 coding region) are apparently normal but resistant to infection with R5 HIV-1. In this study, we found that TAK-779, a nonpeptide compound with a small molec...

Monocyte chemoattractant protein-1 (MCP-1) induces monocyte chemotaxis via interaction with the MCP-1 receptor CCR2. We found that MCP-1 binding to monocytic THP-1 cells was increased by pre-treatment with MCP-1. The amount of CCR2 mRNA and the cell-surface expression of CCR2 were not affected by MCP-1 stimuli. In contrast, the MCP-1-treated THP-1 cells showed a sixfold increase in MCP-1 bindin...

The recent discovery of chemokine receptors as coreceptors for human immunodeficiency virus-type 1 (HIV-1) entry offers new avenues for investigating the pathogenesis of acquired immunodeficiency syndrome (AIDS)-related cytopenias. To this end, we sought to (1) phenotype human hematopoietic cells for CD4 and the HIV-1 coreceptors CXCR4, CCR5, CCR3, and CCR2b; (2) correlate CD4 and chemokine rec...

IFN-alpha-2b, known as potent immune modulator, can either inhibit or enhance immune cell activity within the tightly regulated microenvironment of inflammation, depending upon the concentration of the cytokine and the activation stage of the cell. Chemokine receptors, which not only mediate chemotaxis of immune cells to the site of inflammation but also affect cellular activation by transferri...

there are controversial reports about the effect of captopril on pain modulation. also while captopril may potentiate morphine analgesia, enalapril has not such an effect and interaction of morphine with angiotensin ii receptor antagonists and other angiotensin converting enzyme inhibitors has not been studied yet. therefore, this study was designed to assess the effect of captopril, lisinopril...

The epidermal growth factor receptor (EGFR) is overexpressed in 70-80% of patients with advanced colorectal cancer. development antibodies that target this receptor, cetuximab and panitumumab, lead to an increase overall survival setting. During therapy EGFR inhibitors, the most common toxicity acneiform rash, may represent early biomarker tumor shrinkage might predict effectiveness inhibitors....

Fifty percent of individuals infected with human immunodeficiency virus type 1 (HIV-1) progress to AIDS in the presence of only non-syncytium-inducing (NSI) variants. These rapidly replicating NSI isolates are associated with a high viral load. The question of whether disease progression in the absence of syncytium-inducing (SI) HIV-1 variants is associated with an expansion of the coreceptor r...