نتایج جستجو برای: ccpa

تعداد نتایج: 442  

Journal: :Journal of molecular microbiology and biotechnology 2007
Andrzej T Lulko Girbe Buist Jan Kok Oscar P Kuipers

The pleiotropic regulator of carbon metabolism in Gram-positive bacteria, CcpA, regulates gene expression by binding to so-called cre elements, which are located either upstream or in promoter regions, or in open-reading frames. In this study we compared the transcriptomes of Bacillus subtilis 168 and its ccpA deletion mutant during growth in glucose-containing rich medium. Although growth was ...

Journal: :Nucleic acids research 2001
K Yoshida K Kobayashi Y Miwa C M Kang M Matsunaga H Yamaguchi S Tojo M Yamamoto R Nishi N Ogasawara T Nakayama Y Fujita

We used 2D protein gel electrophoresis and DNA microarray technologies to systematically analyze genes under glucose repression in B:acillus subtilis. In particular, we focused on genes expressed after the shift from glycolytic to gluconeogenic at the middle logarithmic phase of growth in a nutrient sporulation medium, which remained repressed by the addition of glucose. We also examined whethe...

Journal: :Antioxidants & redox signaling 2004
Edith Hochhauser Oleg Kaminski Hemdat Shalom Dorit Leshem Vladimir Shneyvays Asher Shainberg Bernardo A Vidne

The aim of the present study was to investigate the protective role of pharmacological preconditioning on antioxidant enzymes using A(1) and A(3) adenosine receptor agonists in the recovery of the isolated myocardium after cardioplegic ischemia. Two different modes of preconditioning were studied: isolated rat hearts were perfused with A(1) receptor agonist 2-chloro-N(6)-cyclopentyladenosine (C...

Journal: :Journal of molecular modeling 2007
Nadine Homeyer Timm Essigke Heike Meiselbach G Matthias Ullmann Heinrich Sticht

The serine46-phosphorylated form of the bacterial protein HPr fulfils an essential function in carbon catabolite repression (CCR). Using molecular dynamics (MD) we studied the effect of Ser46 phosphorylation on the molecular properties of HPr and its capability to act as the co-repressor of carbon catabolite protein A (CcpA). The calculated pK (a) values for a representative set of HPr(Ser46P) ...

Journal: :Journal of bacteriology 2008
Marcelo Mendez I-Hsiu Huang Kaori Ohtani Roberto Grau Tohru Shimizu Mahfuzur R Sarker

Clostridium perfringens is an anaerobic, gram-positive, spore-forming bacterium responsible for the production of severe histotoxic and gastrointestinal diseases in humans and animals. In silico analysis of the three available genome-sequenced C. perfringens strains (13, SM101, and ATCC13124) revealed that genes that encode flagellar proteins and genes involved in chemotaxis are absent. However...

Journal: :Journal of bacteriology 2002
Holger Ludwig Christoph Meinken Anastasija Matin Jörg Stülke

Bacillus subtilis ccpA mutant strains exhibit two distinct phenotypes: they are defective in catabolite repression, and their growth on minimal media is strongly impaired. This growth defect is largely due to a lack of expression of the gltAB operon. However, growth is impaired even in the presence of glutamate. Here, we demonstrate that the ccpA mutant strain needs methionine and the branched-...

Journal: :Journal of bacteriology 2004
Yiqian Dong Yi-Ywan M Chen R A Burne

In Streptococcus gordonii DL1, inactivation of the ccpA gene and a gene encoding an Fnr-like protein (Flp) demonstrated that CcpA was essential for carbohydrate catabolite repression and that Flp was required for optimal expression and anaerobic induction of the arginine deiminase system.

Journal: :Circulation research 2001
H Takano R Bolli R G Black E Kodani X L Tang Z Yang S Bhattacharya J A Auchampach

We investigated whether activation of A(1) or A(3) adenosine receptors (ARs) induces late preconditioning (PC) against infarction in conscious rabbits using the selective AR agonists 2-chloro-N(6)-cyclopentyladenosine (CCPA) and N(6)-3-iodobenzyladenosine-5'-N-methylcarboxamide (IB-MECA). In vitro radioligand binding and cAMP assays demonstrated CCPA to be approximately 200- to 400-fold selecti...

1999
NELSON L. BERNARDO SHINJI OKUBO MOHAMMED M. MAAIEH MARK A. WOOD RAKESH C. KUKREJA Shinji Okubo Mohammed M. Maaieh Mark A. Wood

Bernardo, Nelson L., Shinji Okubo, Mohammed M. Maaieh, Mark A. Wood, and Rakesh C. Kukreja. Delayed preconditioning with adenosine is mediated by opening of ATP-sensitive K1 channels in rabbit heart. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H128–H135, 1999.—The adenosine agonist 2-chloro-N6-cyclopentyladenosine (CCPA) induces delayed ischemic protection in vivo. We hypothesized that this ...

Journal: :Journal of bacteriology 1998
A J Turinsky F J Grundy J H Kim G H Chambliss T M Henkin

Transcriptional activation of the Bacillus subtilis ackA gene, encoding acetate kinase, was previously shown to require catabolite control protein A (CcpA) and sequences upstream of the ackA promoter. CcpA, which is responsible for catabolite repression of a number of secondary carbon source utilization genes in B. subtilis and other gram-positive bacteria, recognizes a cis-acting consensus seq...

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