The effects of caerulin, a CCK receptor agonist, and proglumide, a receptor antagonist, on hyperalgesia induced by sciatic nerve ligation, was studied in mice. Tolerance to the morphine response was obtained 3,7, 14,21 and 28 days after unilateral sciatic nerve ligation. Maximum hyperalgesia was found 14 days after nerve ligation. Caerulin increased morphine antinociception in nerve-ligated ani...

In order to characterize the biological functions coupled to cholecystokinin (CCK) A and B receptors, the effects of gastrin(2-17 ds) and caerulein were compared. An isolated cell model, the pancreatic acinar cell line AR4-2J, was used and the experiments were carried out in serum-free media. Caerulein was found to evoke no mitogenic effects either alone or in the presence of the CCK antagonist...

Gastric mucosal inflammation causes hypergastrinemia, and gastrin receptors have been detected in several leukocyte types. We have analyzed whether gastrin affects the leukocyte-endothelial cell interactions in vivo by monitoring leukocyte rolling, adhesion, and emigration in rat mesenteric venules using intravital microscopy. Mesenteric superfusion with exogenous gastrin increased these proces...

The role of cholecystokinin (CCK) in modulating feed intake depression in parasite-infected lambs was investigated using CCK receptor antagonists (L364-718 and loxiglumide). Four experiments were carried out using ewe lambs infected with 4000 Trichostrongylus colubriformis larvae/d or non-infected controls (n8, live weight 25 kg). Animals were fed daily on a nutritionally complete pelleted diet...

THE EARLY DAYS OF THE DISCOVERY and identification of different forms of CCK in the GI tract and the abdominal vagus (20), on the one hand, and in the central nervous system (CNS; 7, 17), on the other hand, might have already anticipated important roles of the peptide in various aspects of energy homeostasis, ranging from regulation of feeding behavior and body mass to body temperature control....

cholecystokinin (cck), a peptide hormone found in the gut, is the most abundant peptide neurotransmitters in the brain, and its acute effects on the brain activity have been shown. in this study we aimed to evaluate the acute effects of cck on short-term synaptic plasticity in the dentate gyrus (dg) of the rat hippocampus. via stereotaxic surgery, the stimulating and the recording electrodes we...

1. Nerve growth factor (NGF), a powerful agent for the growth, differentiation and regeneration of lesioned cells of the central and peripheral nervous systems, has in recent years been indicated as a potential therapeutic agent capable of reversing the processes of cell damage in neurodegenerative events in man. Since NGF does not cross the blood-brain barrier and central NGF administration re...

THE EARLY DAYS OF THE DISCOVERY and identification of different forms of CCK in the GI tract and the abdominal vagus (20), on the one hand, and in the central nervous system (CNS; 7, 17), on the other hand, might have already anticipated important roles of the peptide in various aspects of energy homeostasis, ranging from regulation of feeding behavior and body mass to body temperature control....