We studied changes in basal ganglia neuronal activity associated with reaching movements of the arm in two monkeys. Data were obtained from 427 single neuronal units in putamen, 199 in caudate nucleus, and 216 in globus pallidus with multiwire electrodes allowing simultaneous recordings from multiple neurons. In all structures, changes in activity related to movement occurred most often after t...

In postmortem studies of patients with schizophrenia, D2 dopamine receptors in the basal ganglia have been observed to be more numerous than in patients with no history of neurological or psychiatric disease. Because most patients with schizophrenia are treated with neuroleptic drugs that block D2 dopamine receptors in the caudate nucleus, it has been suggested that this increase in the number ...

INTRODUCTION The presence of neuropsychiatry symptoms (hallucinations, delusions and agitation) as stroke-related guideline symptoms, thus forming an acute psychosis of organic cause, are extremely uncommon and often correlate with strategic infarcts (caudate nucleus, striatum and thalamus). CLINICAL CASE We report two cases of stroke-psychosis. Case 1. A 67-year-old man with sudden-onset del...

Fig. 1.-A, Noncontrast CT scan shows vague area of increased attenuation adjacent to head of right caudate nucleus (arrow). B, Coronal T1-weighted (700/ 20/ 4) MR image shows area of decreased signal in white matter adjacent to, and extending into, head of right caudate nucleus (arrow). C, Axial T1-weighted (600/ 20) postcontrast MR image shows no significant contrast enhancement (arrow). D, Ax...

The anterior caudate nucleus is essential for goal-directed behavior because it links outcome information to actions. It is well known that caudate neurons provide a variety of reward-related and action signals. However, it is still unclear how the two signals are integrated. We investigated whether and how outcome risk modulates spatial representation. We recorded neural activity in the anteri...