F. WHO Review History: The WHO Expert Committee on Drug Dependence (ECDD) and other UN bodies reviewed khat at earlier occasions. The Advisory Committee on the Traffic in Opium and Other Dangerous Drugs of the League of Nations discussed on the subject in 1933, but no action was taken. On request of the Commission on Narcotics Drugs (CND), the Expert Committee on Addiction-Producing Drugs (as t...

BACKGROUND Catha edulis Forsk. (Khat) is traditionally used for treating various disorders. Nevertheless there are no reports of any scientific assessment of its psychopharmacological properties. OBJECTIVE Therefore, the current study was designed to evaluate the antidepressant-like activity of Khat ethanolic extract using established animal models of depression and stress. MATERIALS AND ME...

This study investigated the antinociceptive mechanisms of khat extract (100, 200, and 400 mg/kg, i.p.) in four pain models: two thermic (hot plate, tail-flick) and two chemical (acetic acid, formalin) models. Male mice were pretreated intraperitoneally (i.p.) with the opioid receptor blocker naloxone (5 mg/kg), the cholinergic antagonist atropine (2 mg/kg), the selective α1 blocker prazosin (1 ...

The increasing risk of the emergence antimicrobial resistance can be addressed using plant-based botanicals as alternatives to antibiotics. In this in vitro study, properties aqueous and methanolic extracts Catha edulis (Miraa) were tested on select pathogenic bacteria fungi agar well diffusion method. Miraa at 1000 mg/ml, 100 mg. ml, 10 mg/ml concentrations significantly inhibited growth all b...

Fresh leaves of the khat tree (Catha edulis Forsk.) are chewed for their euphoric properties in East Africa and parts of the Middle East, such as The Yemen. This review describes the history, cultivation and constituents of khat, and the social aspects of khat chewing in Yemen. The major pharmacologically active constituent of the fresh leaves is (--)-S-cathinone. The pharmacology of (--)-S-cat...

In this study, we used khat (Catha edulis) leaf extract as a reducing and stabilizing agent for the biosynthesis of zinc oxide nanoparticles (ZnO NPs). The rapid color change solution to pale yellow UV-visible absorption peak at 322 nm confirmed initial formation ZnO NPs. FTIR spectrum analysis revealed contribution bioreduction Zn2+ ions stretching vibration 480 cm-1 also confirms XRD showed c...