INTRODUCTION Interleukin (IL)-37 is a newly identified member of the IL-1 family, and shows a growing role in a variety of diseases. This review aims at summarizing and discussing the role of IL-37 in cardiovascular diseases. METHODS Data for this review were identified by searches of MEDLINE, Embase, and PubMed using appropriate search terms. RESULTS IL-37 is a newly identified cytokine be...

Hugo: TRIM37 Other names: MUL; KIAA0898; POB1; TEF3 Location: 17q23.2 Local order: Genes flanking TRIM37 oriented from centromere to telomere on 17q23 are: RAD51C, 17q22-q23, D51 homolog C (S. Cerevisiae) PPM1E, 17q23.2, protein phosphatase 1E (PP2C domain containing) TRIM37, 17q22-q23, tripartite motif-containing 37 FAM33A 17q23.2, family with sequence similarity 33, member A PRR11(FLJ11029) 1...

Host immune peptides, including cathelicidins, have been reported to possess anticancer properties. We previously reported that LL-37, the only cathelicidin in humans, suppresses the development of colon cancer. In this study, the potential anticancer effect of FK-16, a fragment of LL-37 corresponding to residues 17 to 32, on cultured colon cancer cells was evaluated. FK-16 induced a unique pat...

The native ensemble of caspases is described globally by a complex energy landscape where the binding of substrate selects for the active conformation, whereas targeting an allosteric site in the dimer interface selects an inactive conformation that contains disordered active-site loops. Mutations and posttranslational modifications stabilize high-energy inactive conformations, with mostly form...

introduction: repetitive cortical spreading depression (csd) can lead to cell death in immature brain tissue. caspases are involved in neuronal cell death in several csd-related neurological disorders. yet, whether repetitive csd itself can induce caspase activation in adult or juvenile tissue remains unknown. inducing repetitive csd in somatosensory cortices of juvenile and adult rats in vivo,...

AIMS Heat shock proteins (HSPs), known to inhibit apoptosis and promote cellular survival, are overexpressed in many tumours. We analysed the expression of relevant HSPs and heat shock factor 1 (HSF1) in classical Hodgkin lymphoma (cHL) and their relationship with caspase signalling pathways and patient outcome. METHODS AND RESULTS Using tissue microarrays (TMAs), most cases showed strong imm...

introduction: in this study, the effect of para-nonylphenol as an environmental pollutant on viability, morphology and proliferation of bone marrow mesenchymal stem cells was investigated. methods: bone marrow mesenchymal stem cells of rat were treated with the 0.5, 1, 2.5, 3.5 and 5 μm of paranonylphenol for a period of 21 days, then the viability of the cells were estimated using trypan blue ...

background and objectives: achillea is an ancient medicinal herb. the genus comprises about 100 species which are mostly distributed in northern hemisphere and some have been investigated for different biological activities. there are also several reports in iranian traditional medicine (itm) texts about its anti-tumor effect. the cytotoxic activity of the methanol extract of achillea vermicula...

Mapping the constellation of structural and dynamic changes concurrent with allosteric inhibitor binding to caspase-7, also known as structure–activity relationships (ASARs), reveals nexus between active site remote pocket. These ASARs elucidate link structure catalytic power for caspase-7. Our insights from exploration caspase-7 allostery offer a new path navigating drug discovery. More inform...