BACKGROUND The common cold, the most prevalent contagious viral disease in humans still lacks a safe and effective antiviral treatment. Iota-Carrageenan is broadly active against respiratory viruses in-vitro and has an excellent safety profile. This study investigated the efficacy and safety of an Iota-Carrageenan nasal spray in patients with common cold symptoms. METHODS In a randomized, dou...

BACKGROUND Lipoic acid (LA) was shown to possess anti-inflammatory properties. In this study, we present evidence supporting the hypothesis that the anti-inflammatory properties of LA are associated with the formation of hydrogen sulfide (H2S). METHODS The study was conducted on male albino Swiss mice. The animals were treated with carrageenan by subcutaneous (sc) injection into the right hin...

OBJECTIVE Although electroacupuncture (EA) therapy is used to relieve various kinds of pain, the optimal frequency and duration of EA remain unclear. We investigated the effect of varying frequency and duration of EA during hyperalgesia elicited by carrageenan-induced inflammation. METHODS Carrageenan was administered by subcutaneous intraplantar injection to induce inflammation. Nociceptive ...

Carrageenan potentiated in vivo the primary and secondary responses by concanavalin A (Con A)-bound L1210 murine leukemia vaccine and induced in histocompatible animals enhanced immune resistance to subsequent inoculations of live L1210 cells. This enhancement was critically dependent on the vaccine preparation and the administration timing of carrageenan. Carrageenan potentiated Con A-free vac...

The efficient removal of the antibiotic ciprofloxacin (CIP) from aqueous samples using magnetic nanosorbents prepared three sulfated polysaccharides, κ-, ι- and λ-carrageenan an alkoxysilane agent containing a reactive epoxide ring is described. were characterized in detail FTIR spectroscopy, solid-state 29Si 13C NMR spectroscopy elemental microanalysis. synthesis method was more effective for ...

Background The aim of this study was to evaluate the changes in biomarkers of skeletal muscle proteolysis (atrogin-1, muscle RING finger-1 protein [MuRF-1]) and inflammation (nuclear factor kappa-B) in skeletal muscles of rats under two catabolic conditions, diabetes mellitus (DM) and acute joint inflammation, and the effects of insulin therapy. Materials and methods Male Wistar rats were div...

Carrageenan as an abundant natural carbohydrate could be used as a representative material instead of synthetic polymers. In this work, the degradation of κ-Carrageenan by means of ultrasound irradiation at a frequency of 24 kHz and its combination with heterogeneous Titanium dioxide, followed by a photocatalytic process was investigated. The scission of carrageenan chains induced by a high int...

Conventional guinea pigs provided with a solution of 5% (wt/vol) degraded carrageenan as the sole source of oral fluids developed ulcerations of their ceca and large intestines within 30 days. Similar lesions were not detected in germfree guinea pigs treated in an identical manner, suggesting that an intestinal microflora was necessary for development of intestinal lesions. To simplify the bact...

In this study, we evaluated the mutagenic and antimutagenic activities of carrageenan, a sulfated polysaccharide, and described its mode of action by using an Allium cepa assay. The results indicate that carrageenan is not mutagenic, rather it has significant chemopreventive potential that is mediated by both demutagenic and bio-antimutagenic activities. This compound can adsorb agents that are...

Carrageenans are commercially important sulfated gums found in various species of red seaweeds (Rhodophyta), wherein they serve a structural function similar to that of pectins in land plants. In this study, carrageenan was used independently or in combination with cationic polyacrylamide (CPAM) and/or Al2(SO4)3 to explore its application as a dry strength additive in papermaking. Strength inde...