Previous reports have shown that transmitochondrial mito-mice with nuclear DNA from Mus musculus and mtDNA from M. spretus do not express respiration defects, whereas those with mtDNA from Rattus norvegicus cannot be generated from ES cybrids with mtDNA from R. norvegicus due to inducing significant respiration defects and resultant losing multipotency. Here, we isolated transmitochondrial cybr...

BACKGROUND Double gallbladder (GB) is a rare congenital anomaly of the biliary system characterized by the presence of an accessory GB. CLINICAL FINDINGS A 38-year-old female presented with a history of right upper quadrant (RUQ) pain. Computed tomography (CT) showed a lobulated cystic mass involving the center portion of liver. Magnetic resonance imaging (MRI) additionally revealed a tubular...

Retinal ganglion cell numbers in adult mice vary from 40,000 to 80, 000. Much of this variation and the prominent bimodality of strain averages are generated by allelic variants at the neuron number control 1 (Nnc1) locus on chromosome 11. The Nnc1 locus may modulate either ganglion cell production or the severity of ganglion cell death. Here we have determined what the relative contributions o...

The levels of expression and genomic organization of genes coding for the major urinary proteins (MUPs) were examined in several stocks of wild-derived mice. Levels of MUP mRNA in the liver varied considerably with M. musculus Brno and M. castaneus males having several-fold more MUP RNA than inbred C57BL/6 males, whereas M. hortulanus, M. caroli and M. cervicolor displayed levels much lower tha...

Previous work has shown that the gene for the alpha subunit of androgen-binding protein, Abpa, may be involved in premating isolation between different subspecies of the house mouse, Mus musculus. We investigated patterns of DNA sequence variation at Abpa within and between species of mice to test several predictions of a model of neutral molecular evolution. Intraspecific variation among 10 Mu...

In 1980 Janet Rossant [5] and William I. Frels [6] published their paper, ?Interspecific Chimeras in Mammals: Successful Production of Live Chimeras Between Mus musculus and Mus caroli ,? in Science. Their experiment involved the first successful creation of interspecific mammalian chimeras [7]. Mammalian chimeras [8] are valuable for studying early embryonic development. However, in earlier st...