To the Editor: Corti et al1 recently reported that habitual coffee drinkers display different degrees of caffeine tolerance, depending on the route of caffeine administration. Although the participants did not display elevated systolic blood pressure after consumption of caffeinated coffee, they did after intravenous caffeine administration. In both conditions, the amount of caffeine administer...

Oral fluid compliance monitoring of chronic pain patients is an analytical challenge because of the limited specimen volume and the number of drugs that require detection. This study evaluated oral fluid for monitoring pain patients and compared results to urine studies of similar populations. Oral fluid specimens were analyzed from 6441 pain patients from 231 pain clinics in 20 states. Specime...

BACKGROUND Substance use disorder (SUD) is a global problem with no boundaries, which also afflicts individuals from countries of the Arabian Peninsula. Data from this region is limited. In an effort to develop targeted prevention and intervention initiatives in the United Arab Emirates (UAE), it was necessary to identify the nature of substance use by describing the characteristics of those us...

BACKGROUND Reports of chronic pain and associated opioid use, abuse, and fatalities continue to increase at an alarming rate, not only in the United States but also across the globe. In light of the many resultant fatalities, multiple authors and authorities have cautioned against the excessive use of opioids. Consequently, the Food and Drug Administration, Drug Enforcement Administration, and ...

This report introduces an improved method of detecting chemical-induced morphological transformation of A-31-1-13 BALB/c-3T3 cells. The new procedure uses an increased target cell population to assess chemical-induced damage by increasing the initial seeding density and by delaying the initiation time of chemical treatment. Furthermore, a newly developed co-culture clonal survival assay was use...

BACKGROUND N-acetylcysteine is used to treat acetaminophen toxicity and is available in both intravenous and oral formulations. Our report describes a patient treated with intravenous N-acetylcysteine for acetaminophen toxicity who died after an anaphylactoid reaction following initiation of the infusion. OBJECTIVE Clinicians should be aware of potential complications when deciding on which f...

8202 The effect of iproniazid on the metabolism of dl-epinephrine-2-C14 in the human. N. Kirshner, NcC. Goodall, L. Rosen. 1 8203 Substrate requirements for the positive inotropic action of arsenate on electrically-stimulated rat ventricle strips. J. N. Covin, D. A. Berman. 8 8204 Oxidation of glucose-l-C14, glucose-6-Cl4 and pyruvate-2-C14 by contracting rat ventricle strips in the presence an...

Descrição do método de coleta de evidência Este estudo revisou artigos nas bases de dados do MEDLINE (PubMed) e demais fontes de pesquisa sem limite de tempo. Para tanto, adotou-se a estratégia de busca baseada em perguntas estruturadas na forma (P.I.C.O.) das seguintes iniciais: “Paciente”; “Intervenção”; “Controle”; “Outcome”. Como descritores, utilizaram-se: Pergunta 1: low back pain AND (an...