background: the poisoning is mostly due to suicide and is observed in younger age groups. the systemic manifestations of alp poisoning are common but pernicious manifestations of them are cardiotoxicity, shock, and ards. the clinical hallmark of cardiotoxicity is arrhythmia. the aim of this study was to investigate cardiac arrhythmias in patients poisoned with alp who were admitted to razi hosp...

Introduction: Anthracyclines are one of the classes of chemotherapy drugs that  are widely used to treat many types of cancers including breast cancer. Taking this class of medications has a significant relationship with cardiac dysfunction. N-acetylcysteine has antioxidant properties and may be effective in preventing cardiac dysfunctions. In this study, we investigated the effect of N-acetylc...

Background: The poisoning is mostly due to suicide and is observed in younger age groups. The systemic manifestations of ALP poisoning are common but pernicious manifestations of them are cardiotoxicity, shock, and ARDS. The clinical hallmark of cardiotoxicity is arrhythmia. The aim of this study was to investigate cardiac arrhythmias in patients poisoned with ALP who were admitted to Razi Ho...

Doxorubicin (DOX) is an anthracycline antibiotic with broad spectrum anti-tumour activity. Its effectiveness has been limited by the occurrence of dose-related myocardial and bone marrow toxicity. As oxidative stress is the main factor in DOX-induced cardiotoxicity, we presumed that agents which enhance endogenous antioxidants can prevent DOX induced cardiotoxicity. Animals received either DOX ...

RATIONALE Despite intense interest in strategies to predict which kinase inhibitor (KI) cancer therapeutics may be associated with cardiotoxicity, current approaches are inadequate. Sorafenib is a KI of concern because it inhibits growth factor receptors and Raf-1/B-Raf, kinases that are upstream of extracellular signal-regulated kinases (ERKs) and signal cardiomyocyte survival in the setting o...

OBJECTIVES The aim of this study was to determine if individual or multiple biomarkers are associated with cardiotoxicity in patients with breast cancer undergoing cancer therapy. BACKGROUND Current methods to identify patients at risk for cardiotoxicity from cancer therapy are inadequate. METHODS We measured 8 biomarkers in a multicenter cohort of 78 patients with breast cancer undergoing ...

The long-term usage of doxorubicin (DOX) is largely limited due to the development of severe cardiomyopathy. Many studies indicate that DOX-induced cardiac injury is related to reactive oxygen species generation and ultimate activation of apoptosis. The role of novel mitochondrial fission protein 1 (Mtfp1) in DOX-induced cardiotoxicity remains elusive. Here, we report the pro-mitochondrial fiss...

The cardiotoxicity of anticancer agents can lead to significant complications that can affect patients being treated for various malignancies. The severity of such toxicity depends on many factors such as the molecular site of action, the immediate and cumulative dose, the method of administration, the presence of any underlying cardiac condition, and the demographics of the patient. Moreover, ...

The cardiotoxicity of anticancer agents can lead to significant complications that can affect patients being treated for various malignancies. The severity of such toxicity depends on many factors such as the molecular site of action, the immediate and cumulative dose, the method of administration, the presence of any underlying cardiac condition, and the demographics of the patient. Moreover, ...

BACKGROUND Biomarkers may play an important role in identifying patients at risk for cancer therapy cardiotoxicity. Our objectives were to define the patterns of change in biomarkers with cancer therapy and their associations with cardiotoxicity. METHODS In a multicenter cohort of 78 breast cancer patients undergoing doxorubicin and trastuzumab therapy, 8 biomarkers were evaluated at baseline...