BACKGROUND Intestinal mucosal ischaemia can occur in infants and children during and after cardiac surgery. Severe decreases in mucosal perfusion may cause complications such as necrotizing enterocolitis and postoperative mortality. We investigated gut permeability in paediatric patients undergoing cardiac surgery using the dual sugar permeability test and absorption of two other saccharides. ...

OBJECTIVES To investigate the effects of the ultrapotent poly(adenosine 5'-diphosphate-ribose) polymerase (PARP) inhibitor INO-1001 on cardiac and mesenteric function during reperfusion in an experimental model of cardiopulmonary bypass with cardioplegic arrest. DESIGN Prospective, randomized, and blinded experimental study. SETTING Research laboratory. SUBJECTS : Twelve anesthetized dogs...

OBJECTIVES Malignant hyperthermia susceptibility is an important risk factor during general anesthesia. Affected patients have an asymptomatic but potentially lethal hypermetabolic reaction after contact with volatile anesthetics or succinylcholine. Classic symptoms include hemodynamic instability, combined with acidosis, rigor, and hyperthermia. During cardiopulmonary bypass, these signs may b...

INTRODUCTION AND OBJECTIVES The transient myocardial ischemia that occurs during cardiac surgery leads to oxidative stress and the production of free radicals. The resulting damage can be reduced if cardiopulmonary bypass is avoided. We obtained indirect measures of the oxidative damage occurring during cardiac surgery by monitoring the glutathione system and we studied the influence of cardiop...

myocardial bridging with systolic compression of the left anterior descending coronary artery (lad) may be associated with myocardial ischemia. in symptomatic myocardial bridging unresponsive to medical treatment, surgical unroofing of the left lad can be performed. little information is available about the long-term prognosis of patients with this coronary anomaly after the surgical unroofing,...

BACKGROUND Hyperglycemia is commonly present in the perioperative period in patients undergoing cardiac surgery, even during administration of insulin. A direct relationship between postoperative hyperglycemia and mortality has been established in diabetic patients undergoing cardiac surgery. However, this relationship might be confounded because patients with poor outcome receive more glucogen...

BACKGROUND Despite the continuing improvements in surgical and cardiopulmonary bypass techniques during cardiac surgery, stroke remains a devastating complication. This study aimed to identify the preoperative and intraoperative risk factors for developing a perioperative stroke in patients undergoing coronary artery bypass graft surgery on cardiopulmonary bypass. METHODS A total of 4,380 con...

INTRODUCTION Cardiopulmonary bypass causes a series of inflammatory events that have adverse effects on the outcome. The release of cytokines, including interleukins, plays a key role in the pathophysiology of the process. Simultaneously, cessation of ventilation and pulmonary blood flow contribute to ischaemia-reperfusion injury in the lungs when reperfusion is maintained. Collapse of the lung...

Background : Quests for doing coronary artery bypass surgery by a technique with lower complications is going on, for this aim many studies compared patients undergoing CABG with or without cardiopulmonary bypass. This study was carried out to compare laboratory findings after coronary artery bypass in these two groups of patients. Materials and Methods: In a retrospective study, 167 patients ...