INTRODUCTION Carcinoid tumors are the most common type of small bowel tumor, and the incidence is rising. The majority of small bowel carcinoid tumors arise within 60 cm of the ileocecal valve. The addition of ileoscopy to screening colonoscopy can detect asymptomatic small bowel carcinoid tumors and improve long-term prognosis through early surgical resection. Ileoscopy is a brief procedure wi...

PURPOSE The carcinoid tumor was recently categorized as a malignant disease due to its possibility of metastasis. This study was aimed to investigate the clinical characteristics and the metastatic rate of colorectal carcinoid tumors. METHODS Charts were reviewed for 502 patients diagnosed with and treated for colorectal carcinoid tumors between January 2006 and December 2009. The location, s...

INTRODUCTION Mixed adeno-neuroendocrine carcinoma (MANEC) is a rare pathological diagnosis recently defined by the World Health Organization (WHO) in 2010. Prior to the definition by the WHO, tumors with both adenocarcinoma and neuroendocrine components were given multiple pathological designations making it difficult to characterize the disease. The aim of our study is to better characterize M...

Carcinoid tumors are rare and slow growing malignancies derived from enterochromaffin cells. Two-thirds of carcinoid tumors arise in the gastrointestinal tract, and in 3% of these cases the primary site cannot be determined. Presenting symptoms depend on the location of the primary tumor but may be nonspecific, and in 13% of patients distant metastases are discovered on diagnosis. The classic c...

In this issue 1-5 Bronchial carcinoid Tumors: diagnosis and managemenT 5 conTinuing medical educaTion evenTs 6-8 selecTions from The Peer-reviewed liTeraTure 9 lung cancer meeTings and symPosia Carcinoid tumors are rare neuroendocrine tumors that arise from enterochromaffin cells found throughout the gastrointestinal and bronchopulmonary systems. Carcinoids are predominantly found in the gastro...

Introduction Carcinoid was first characterized by Lubarsh in 1888. However, Ranson is given credit for the first description of a carcinoid of the ileum in 1890. The term ‘karzinoide’ was used first by Oberndorfer in 1907 to describe tumors that behaved in a more indolent fashion than typical adenocarcinomas. In 1928, Masson stated that carcinoids should be considered as endocrine tumors since ...

We examined the effects of a newly synthesized gastrin receptor antagonist, AG-041R, on the growth of enterochromaffin-like (ECL) carcinoid tumors in Mastomys natalensis both in vitro and in vivo. AG-041R was as potent as the well known gastrin antagonist L365,260 in inhibiting not only the gastrin-induced release of histamine from but also histidine decarboxylase (HDC) gene expression in the E...

Carcinoid is a rare gastrointestinal tumor. We have noticed a high incidence of carcinoid in our patient population during the gastric reduction-duodenal switch operation. Further studies are needed to identify any potential correlation between morbid obesity and carcinoid tumors.

Purpose: This study aimed to investigate the expression of the ErbB family of receptor tyrosine kinases in pulmonary typical carcinoid and atypical carcinoid tumors and to understand the role of epidermal growth factor receptor (EGFR) signaling in pulmonary carcinoid tumor proliferation. Experimental Design: Surgically resected typical carcinoid (n = 24) and atypical carcinoid (n = 7) tumor tis...

PURPOSE Carcinoids are neuroendocrine tumors and most frequently occur within tissues derived from the embryonic gut. These tumors can occur in any organ site but are rare in the testis. The cell type giving rise to testicular carcinoid is unknown. We hypothesized that testicular carcinoid may have a germ cell origin. EXPERIMENTAL DESIGN We describe our analysis of protein and genetic markers...