the present study concerned with the development and characterization of metronidazole microcapsules prepared by thermal change method using different ratios (1:1, 1:2 and 1:4) of ethyl cellulose in order to select the best microcapsule formulation with a good encapsulation efficiency and drug release profile. the obtained microcapsules were discrete, spherical with free flowing properties and ...

Nanoemulsions (NEs) are used as transdermal drug delivery systems for systematic therapeutic purposes. We hypothesized that the skin permeation profile of an NE could be modulated by incorporating it into a hydrogel containing differing proportions of thickening agent. The objectives of this study were as follows: 1) to determine the stability and skin irritability of NE gels (NGs) containing 1...

1. The mechanism of interaction of the polyacrylates, carbopols with the mucus barrier in vivo has been investigated in vitro. 2. Carbopol caused a dramatic increase in the viscosity of porcine gastric mucin solutions that was up to 19-fold greater than that of the sum of the individual polymers. 3. The mucin-carbopol interaction was stable after an initial 30 min period for up to 36 h at 25 de...

The study was aimed to prepare gastro retentive floating microsphere of Ranitidine Hydrochloride by Ionotropic Gelation technique and solvent evaporation using the different carriers’ ratios (Carbopol 934, Chitosan, sodium alginate). Both natural synthetic polymers have been used microspheres evaluated relevant parameters. There no drug carrier interactions assessed from FTIR. Depending upon ra...

The herbal cosmetics are natural and free from all the harmful synthetic chemicals which generally may turn out to be lethal skin, ingredient used assures no side effect one can applied them any time. So, cosmetic more referable as compared synthetics one. purpose of present work is formulate evaluated hand wash using ingredients promote personal hygiene. formulated was for different parameters...

The Asian swamp eel (Monopterus albus), is commonly distributed in countries. However, its therapeutic potential has not been thoroughly investigated yet. current study aimed to evaluate the in-vivo properties of skin mucus this fish. was collected fleshly and topical gel with carbopol 934 formulated antibacterial activity on infected rats. Sprague Dawley rats were used divided into 4 groups ne...

Abstract: Background: Hydrotropic solid dispersion has been reported as a potential process to improve the poor solubility of drugs using conventional hydrotropes. The presented investigation described water-soluble hydrotropic system for Meloxicam (MX) sodium benzoate hydrotrope enhance and topical delivery. Thus, was prepared, characterized, converted into HSD-Meloxicam gel. prepared gel furt...

Within the current study, a delivery system based on a novel polymer-lectin conjugate (carbopol-lectin) was evaluated for the oral delivery of therapeutic peptides and proteins. It was demonstrated that covalent attachment of lectin to carbopol does neither decrease nor abolish the specific binding properties of lectin. Bioadhesion studies revealed that liposomes coated with carbopol lectin are...

ii ACKNOWLEDGEMENTS I would like to thank my major professor, Dr. Atul J. Shukla for his valuable support and guidance. I would also like to thank my committee members, Dr. for their valuable suggestions and guidance. I would also like to thank my present lab colleagues Dr. for their guidance and help. I thank my parents, wife and sister for supporting me at all times. My success has always bee...

The aim of this study was to assess applicative properties of the produced acc. to own prescription dental anti-inflammatory hydrogel with Carbopol 974P. Ketoprofen pharmaceutical availability was tested from hydrogel with Carbopol 974P and to compare - from hydrogels of similar prescription produced on the base of xanthan gum carboxymethylcellulose sodium salt. Very high pharmaceutical availab...