Mucoadhesive microbeads of low methoxyl pectin were prepared, either alone or in combinations with hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, methyl cellulose and carbopol 934P, by ionotropic gelation. The influence of copolymers on mucoadhesivity, microbeads characteristics and in vitro drug release was investigated. Spherical microbeads with 78.69±0.59 to 85.84±0.78% drug...

We treated 20 consecutive patients suffering from staphylococcal keratitis with topical fusidic acid 1% suspension in a carbomer gel. Fifteen (79%) of the isolated Staphylococcus epidermidis strains were resistant to methicillin, but all were sensitive to fusidic acid by in-vitro testing. The keratitis showed evidence of healing in 17 (85%) of the 20 patients. The healing times ranged between 5...

This is a description of an unusual case of conjunctivitis caused by a trombiculid red mite, Neotrombicula autumnalis. The patient's condition improved only after its removal and with application of carbomer gel eye drops. There have been reports of increasing numbers of severe cases of trombiculosis over the last 15 years particularly in Germany and a number of cases have also been reported in...

Every year there is an increase in the number of cases hypersensitivity to bites from various insects. A local allergic reaction occurs within a few minutes and accompanied by acute pain at site bite, severe itching, hyperemia, appearance papules, tissue edema, sometimes small-point rash around. Considering small drugs for therapy manifestations unidirectional nature their action, it urgent dev...

Purnose The incorporation of polymers into artificial tears both increases the thickness of the precorneal tear film and decreases the rate of drainaae of the for8nulations. On the basis of these effects, we hypothesized that a time study of the artificial increase in tear volume induced by such formulations could be a useful method of assessing their precorneal residence time. Methods New Zeal...

BACKGROUND Compound Arnebiae radix oil has been clinically applied to treat burns and scalds for a long time. However, it is unstable and inconvenient to use. The aim of this study was to prepare a compound Arnebiae radix microemulsion gel for transdermal delivery system and evaluate its characteristics. MATERIALS AND METHODS Based on the solubility of Shikonin, the active component of Arnebi...

Nifedipine is an antihypertensive BCS class II drug which has poor bioavailability when given orally. The objective of the present study was to increase the bioavailability of nifedipine, by formulation and evaluation of a buccoadhesive liquisolid system using magnesium aluminium silicate (Neusilin) as both carrier and coating material and dissolution media were selected based on the solubility...

mulation of semisolid bases, generally with a significant influence on their rheological properties. When organic amines are employed as neutralizing agents of carbopols, it is possible to gel many semipolar liquids and mixtures of these liquids with water. Compatibility of the polymer and non-polar solvents depends on the formation of ion pairs with the amine. Although alcohols are useful for ...